Fluvoxamine does not interact with alcohol or potentiate alcohol-related impairment of cognitive function
| Autor: | Maikel Raghoebar, Antoine Cournot, Keith Wesnes, Lloyd A Stevens, Robert L Holland, Jaap van Harten |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male media_common.quotation_subject Administration Oral Alcohol Fluvoxamine Pharmacology chemistry.chemical_compound Cognition Double-Blind Method Pharmacokinetics Memory Reference Values Oral administration Humans Medicine Pharmacology (medical) Adverse effect media_common Dose-Response Relationship Drug Ethanol business.industry Drug Synergism chemistry Pharmacodynamics Anesthesia Injections Intravenous Reuptake inhibitor business Psychomotor Performance Vigilance (psychology) medicine.drug |
| Zdroj: | Clinical Pharmacology and Therapeutics. 52:427-435 |
| ISSN: | 1532-6535 0009-9236 |
| DOI: | 10.1038/clpt.1992.166 |
| Popis: | OBJECTIVE:To assess whether fluvoxamine alters the pharmacokinetics of alcohol or potentiates alcohol-related impairment of cognitive function. METHODS:The study design required partially "blinded" balanced crossover studies, each involving 12 healthy male volunteers who each received a 40 gm dose of intravenous or oral alcohol after single and multiple doses of 50 mg fluvoxamine. Main outcome measures for pharmacokinetics were venous blood alcohol and plasma fluvoxamine. Main outcome measures for pharmacodynamics were word recall, simple and choice reaction time, number vigilance, memory scanning, and word recognition. RESULTS:The pharmacokinetics of intravenous alcohol were not affected by concomitant administration of fluvoxamine. Compared with placebo-alcohol, alcohol slightly increased the rate of fluvoxamine absorption, but the area under the plasma concentration-time curve from 0 to 12 hours at steady state was unchanged. As expected, alcohol significantly impaired cognitive function in volunteers. However, fluvoxamine did not potentiate the effects of alcohol and in some instances appeared to reverse the effects or reduce their duration. Fluvoxamine was well tolerated: only mild adverse effects were reported, and none of those required intervention. CONCLUSION:Fluvoxamine does not interact significantly with alcohol or potentiate alcohol-related impairment of cognitive function. |
| Databáze: | OpenAIRE |
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