Heart failure assessed based on plasma B-type natriuretic peptide (BNP) levels negatively impacts activity of daily living in patients with hip fracture
Autor: | Micihko Matsuura, Sumiko Shiba, Yusuke Tamamura, Toshio Nishikimi |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
Activities of daily living medicine.medical_treatment 030204 cardiovascular system & hematology Biochemistry Severity of Illness Index 0302 clinical medicine Interquartile range Activities of Daily Living Natriuretic Peptide Brain Natriuretic peptide Medicine and Health Sciences Biomechanics 030212 general & internal medicine Musculoskeletal System Aged 80 and over Univariate analysis Hip fracture Multidisciplinary Rehabilitation Hand Strength Age Factors Regression analysis C-Reactive Proteins Treatment Outcome Cardiology Medicine Female Anatomy Research Article medicine.medical_specialty medicine.drug_class Science Nutritional Status Pelvis 03 medical and health sciences Sex Factors Internal medicine Albumins medicine Humans Skeleton Aged Retrospective Studies Heart Failure Hip business.industry Hip Fractures Biology and Life Sciences Proteins medicine.disease Health Care Geriatrics Heart failure Quality of Life Linear Models business human activities |
Zdroj: | PLoS ONE PLoS ONE, Vol 15, Iss 8, p e0237387 (2020) |
ISSN: | 1932-6203 |
Popis: | Several studies have shown that nutrition and muscle strength were associated with functional recovery in patients with hip fracture. However, the impact of heart failure on the improvement of activity of daily living (ADL) in patients with hip fracture have not been fully investigated. The purpose was investigating the effect of heart failure on the ADL improvement by rehabilitation in patients with hip fracture. A total of 116 patients with hip fracture discharged from our convalescent rehabilitation ward were studied. Heart failure was assessed based on plasma B-type natriuretic peptide (BNP) levels on admission. ADL was assessed based on rehabilitation effectiveness (REs), which was calculated using the FIM instrument. Clinical, demographic, and nutritional variables were measured. Multiple regression analysis was performed with REs as the dependent variable; variables showing significant correlation with REs in univariate analyses were selected as independent variables. Based on plasma BNP levels, we assigned 39 patients to a Low group: 22 (17-25) median (interquartile) pg/mL, 39 to a Middle group: 52 (42-65) pg/mL, and 38 to a High group: 138 (93-209) pg/mL. REs, handgrip strength, Hb, albumin, and GNRI were higher and age was younger in the Low group than High group (each p < 0.01, respectively). Multiple linear regression analysis revealed that age (p < 0.05), sex (p < 0.05), handgrip strength (p < 0.01), FOIS at admission (p < 0.01), rehabilitation time per day (p < 0.01), and BNP (p < 0.05) were significantly associated with REs. The effect of rehabilitation on ADL improvement was significantly blunted in the High group compared to the Low group. In conclusion, these results suggest that heart failure assessed based on plasma BNP levels negatively impacts improvements in ADL achieved through rehabilitation in patients with hip fracture. |
Databáze: | OpenAIRE |
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