Longitudinal changes in global structural brain connectivity and cognitive performance in former hospitalized COVID‑19 survivors: an exploratory study

Autor: B. Tassignon, A. Radwan, J. Blommaert, L. Stas, S. D. Allard, F. De Ridder, E. De Waele, L. C. Bulnes, N. Hoornaert, P. Lacor, E. Lathouwers, R. Mertens, M. Naeyaert, H. Raeymaekers, L. Seyler, A. M. Van Binst, L. Van Imschoot, L. Van Liedekerke, J. Van Schependom, P. Van Schuerbeek, M. Vandekerckhove, R. Meeusen, S. Sunaert, G. Nagels, J. De Mey, K. De Pauw
Přispěvatelé: Human Physiology and Sports Physiotherapy Research Group, Physiotherapy, Human Physiology and Anatomy, Biostatistics and medical informatics, Public Health Sciences, Internal Medicine, Clinical sciences, Intensive Care, Brain, Body and Cognition, Psychology, Faculty of Psychology and Educational Sciences, Faculty of Medicine and Pharmacy, UZB Other, Microbiology and Infection Control, Faculty of Physical Education and Physical Therapy, Radiology, Supporting clinical sciences, Neurology, Laboratorium for Micro- and Photonelectronics, Artificial Intelligence supported Modelling in clinical Sciences, Electronics and Informatics, Neuroprotection & Neuromodulation, Medical Imaging, Rectorate, Experimental and Applied Psychology, Brubotics Rehabilitation Research Center, International Relations and Mobility, Body Composition and Morphology
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: EXPERIMENTAL BRAIN RESEARCH
ISSN: 0014-4819
1432-1106
Popis: Background Long-term sequelae of COVID-19 can result in reduced functionality of the central nervous system and substandard quality of life. Gaining insight into the recovery trajectory of admitted COVID-19 patients on their cognitive performance and global structural brain connectivity may allow a better understanding of the diseases' relevance. Objectives To assess whole-brain structural connectivity in former non-intensive-care unit (ICU)- and ICU-admitted COVID-19 survivors over 2 months following hospital discharge and correlate structural connectivity measures to cognitive performance. Methods Participants underwent Magnetic Resonance Imaging brain scans and a cognitive test battery after hospital discharge to evaluate structural connectivity and cognitive performance. Multilevel models were constructed for each graph measure and cognitive test, assessing the groups' influence, time since discharge, and interactions. Linear regression models estimated whether the graph measurements affected cognitive measures and whether they differed between ICU and non-ICU patients. Results Six former ICU and six non-ICU patients completed the study. Across the various graph measures, the characteristic path length decreased over time (β = 0.97, p = 0.006). We detected no group-level effects (β = 1.07, p = 0.442) nor interaction effects (β = 1.02, p = 0.220). Cognitive performance improved for both non-ICU and ICU COVID-19 survivors on four out of seven cognitive tests 2 months later (p Conclusion Adverse effects of COVID-19 on brain functioning and structure abate over time. These results should be supported by future research including larger sample sizes, matched control groups of healthy non-infected individuals, and more extended follow-up periods.
Databáze: OpenAIRE
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