Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granuloma of the jaws? A double-blind clinical trial
| Autor: | Tuba Karagah, Sara Amanpour, B. Zamiri, Sorena Fardisi, Reza Tabrizi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Calcitonin Male medicine.medical_specialty Adolescent medicine.medical_treatment Placebo 03 medical and health sciences 0302 clinical medicine Calcitonin nasal Double-Blind Method Granuloma Giant Cell Recurrence Secondary Prevention medicine Humans Mandibular Diseases Bone Density Conservation Agents business.industry Nasal Sprays 030206 dentistry medicine.disease Maxillary Diseases Curettage Surgery Clinical trial Otorhinolaryngology Nasal spray 030220 oncology & carcinogenesis Maxilla Female Oral Surgery business Central giant-cell granuloma |
| Zdroj: | International Journal of Oral and Maxillofacial Surgery. 45:756-759 |
| ISSN: | 0901-5027 |
| Popis: | Recurrence is a major problem following the treatment of aggressive central giant cell granuloma (CGCG). The aim of this study was to compare the frequency of recurrence between patients who received calcitonin nasal spray after curettage of CGCGs and those who did not. A double-blind clinical trial was designed. Patients were allocated to one of two groups: those in the calcitonin group underwent curettage and received calcitonin salmon nasal spray 200IU/day once a day for 3 months after surgery; those in the control group underwent curettage of CGCGs and received a placebo once a day for 3 months after surgery. All patients were followed for 5 years after surgery. Twenty-four patients were treated in the two groups. There was no difference in age, sex, tumour size, or tumour location between the two groups (P>0.05). Eight of the 24 patients (33.3%) had recurrences during the follow-up period: one in the calcitonin group (9.1%) and seven in the control group (53.8%). Analysis of the data demonstrated a significant difference between the two study groups (P=0.033). It appears that calcitonin nasal spray may reduce the frequency of recurrence in aggressive CGCGs in the mandible and maxilla. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect