Dynamic Release of Cdc34 from SCF
| Autor: | Rory K. Geyer, Dieter A. Wolf |
|---|---|
| Rok vydání: | 2003 |
| Předmět: | |
| Zdroj: | Cell. 114:532-533 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/s0092-8674(03)00682-2 |
| Popis: | Polyubiquitylation is a complex but poorly understood biochemical reaction catalyzed by E3 ubiquitin ligases. In this issue of Cell, Deffenbaugh et al. provide experimental support for a model in which the dynamic release of the ubiquitin-charged E2 Cdc34 from its primary binding site within the rigid cradle-like SCF E3 complex allows for unexpected spatial flexibility to assemble a polyubiquitin chain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|