Sequential changes in urinary catecholamine in the transition from benign to malignant hypertension in rats
| Autor: | Kazuhide Sugiyama, Shoji Sesoko, Noriko Akema, Yoshihiro Kaneko, Toshiyoshi Matsukawa, Hiroshi Iwasawa, Hiroshi Shionoiri |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Epinephrine Physiology Urinary system Sodium Chloride Kidney Rats Inbred WKY Hypertension Malignant Norepinephrine (medication) Excretion Norepinephrine Catecholamines Spontaneously hypertensive rat Rats Inbred SHR Internal medicine medicine Animals cardiovascular diseases Fibrinoid necrosis Desoxycorticosterone urogenital system business.industry medicine.disease Rats Blood pressure Endocrinology Hypertension cardiovascular system Catecholamine Cardiology and Cardiovascular Medicine business hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology medicine.drug |
| Zdroj: | Japanese Circulation Journal. 52:197-202 |
| ISSN: | 1347-4839 0047-1828 |
| DOI: | 10.1253/jcj.52.197 |
| Popis: | The sequential changes in 24-hour urinary norepinephrine (NE) and epinephrine (E) excretion levels were measured in spontaneously hypertensive rats (SHR) that received deoxycorticosterone acetate (DOCA) and 1% NaCl drinking water. These were compared with those from control SHR and similarly treated Wistar-Kyoto rats (WKY). Blood pressure, NE and E increased progressively in DOCA-SHR group, and NE (2392 +/- 94 vs. 998 +/- 49 ng/day) and E (250 +/- 21 vs. 116 +/- 6 ng/day) exceeded twice that of the control SHR group in the sixth week of DOCA treatment. In WKY rats, NE (1372 +/- 48 vs. 968 +/- 37 ng/day) and E (147 +/- 9 vs. 121 +/- 7 ng/day) levels were significantly higher in rats given DOCA than those in control group in the sixth week of the treatment, but were not so remarkably high as in DOCA-SHR group. A histological examination of DOCA-SHR kidneys revealed fibrinoid necrosis in the vascular walls. These data suggest that sympathoadrenal activity plays an important role in the development of malignant hypertension in DOCA-SHR group. |
| Databáze: | OpenAIRE |
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