Bacterial Growth Rate and Host Factors as Determinants of Intracellular Bacterial Distributions in Systemic Salmonella enterica Infections
| Autor: | Andrew J. Grant, Simon Clare, Gemma L. Foster, Duncan J. Maskell, Pietro Mastroeni, Trevelyan J. McKinley, Sam P. Brown |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
Salmonella Cytoplasm Immunology Colony Count Microbial Bacterial growth medicine.disease_cause Microbiology Mice Immunity In vivo medicine Animals Mice Inbred BALB C Phagocytes Salmonella Infections Animal biology Host (biology) Salmonella enterica Bacterial Infections Models Theoretical biology.organism_classification Virology Mice Inbred C57BL Infectious Diseases Host-Pathogen Interactions Parasitology Female Intracellular Bacteria |
| Zdroj: | Grant, A J, Foster, G L, McKinley, T J, Brown, S P, Clare, S, Maskell, D J & Mastroeni, P 2009, ' Bacterial Growth Rate and Host Factors as Determinants of Intracellular Bacterial Distributions in Systemic Salmonella enterica Infections ', Infection and Immunity, vol. 77, no. 12, pp. 5608-5611 . https://doi.org/10.1128/IAI.00827-09 |
| Popis: | Bacteria of the speciesSalmonella entericacause a range of life-threatening diseases in humans and animals worldwide. The within-host quantitative, spatial, and temporal dynamics ofS. entericainteractions are key to understanding how immunity acts on these infections and how bacteria evade immune surveillance. In this study, we test hypotheses generated from mathematical models of in vivo dynamics ofSalmonellainfections with experimental observation of bacteria at the single-cell level in infected mouse organs to improve our understanding of the dynamic interactions between host and bacterial mechanisms that determine net growth rates ofS. entericawithin the host. We show that both bacterial and host factors determine the numerical distributions of bacteria within host cells and thus the level of dispersiveness of the infection. |
| Databáze: | OpenAIRE |
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