Regional coronary venous oxygen saturation and myocardial oxygen tension following abrupt changes in ventricular pressure in the isolated dog heart
| Autor: | Walter J. Gamble, R. Grier Monroe, Jonathan Weisul, Donald C. Fyler, C. Grant Lafarge |
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| Rok vydání: | 1974 |
| Předmět: |
Left Ventricular Systolic Pressure
medicine.medical_specialty Physiology Heart Ventricles Partial Pressure Transducers Blood Pressure In Vitro Techniques Veins Dogs Oxygen Consumption Ischemia Internal medicine medicine Methods Animals Oximetry Anrep effect business.industry Myocardium Coronary Vessels Oxygen tension Electrodes Implanted Oxygen medicine.anatomical_structure Blood pressure Ventricle Anesthesia Ventricular pressure Cardiology Venous oxygen saturation Dog heart Cardiology and Cardiovascular Medicine business Endocardium |
| Zdroj: | Circulation research. 34(5) |
| ISSN: | 0009-7330 |
| Popis: | Regional coronary venous oxygen saturation and myocardial oxygen tension (PO 2 ) in isolated dog hearts were measured using two different methods--a new technique of microscopic oximetry and an improved oxygen electrode. Both methods yielded similar results. In studies of the isolated perfused dog heart developing a constant left ventricular systolic pressure, mean coronary venous oxygen saturation of blood in the subendocardial veins of the left ventricle was significantly lower than that in the subepicardial veins. Following abrupt increases in systolic pressure, subendocardial coronary venous saturations fell to even lower levels. Following abrupt decreases in systolic pressure, the mean subendocardial coronary venous oxygen saturation increased to levels above those in the blood of the subepicardial veins. These findings agree with the hypothesis that transient underperfusion and overperfusion of the subendocardial layers of the left ventricle occur with abrupt increases and decreases in ventricular pressure, respectively. |
| Databáze: | OpenAIRE |
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