A rotating cerium anode X-ray system allows visualization of intramural coronary vessels after cardiac stem cell therapy for myocardial infarction
| Autor: | Toshihiko Ueda, Naoto Fukuyama, Yoshiro Shinozaki, Yoshimori Ikeya, Takashi Shiraishi, Chiharu Tanaka, Kikue Todoroki, Toru Hosoda, Hidezo Mori, Toru Shizuma |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Physiology Myocardial Infarction chemistry.chemical_element 030204 cardiovascular system & hematology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Dogs Cardiac Stem Cell Internal medicine Medicine Animals Myocardial infarction business.industry X-Rays X-ray Heart Cerium medicine.disease Coronary Vessels Anode Disease Models Animal medicine.anatomical_structure chemistry Microangiography Cardiology Stem cell Nuclear medicine business Artery Stem Cell Transplantation |
| Zdroj: | The journal of physiological sciences : JPS. 68(4) |
| ISSN: | 1880-6562 |
| Popis: | Conventional angiography is insufficient for evaluating the therapeutic effect of cardiac regeneration therapy. A microangiographic X-ray system using a cerium anode was developed. Cerium has a characteristic X-ray with a peak at 34.6 keV, which allows visualization of tiny amounts of iodine. The performance of the cerium anode X-ray system was evaluated in two excised normal canine hearts and in excised ischemic canine hearts treated with c-kit-positive cardiac stem cells (5 canines) or without cells (5 control canines). In the normal canines, branches penetrating from the left anterior descending artery into the myocardium were visualized, down to third-order branches. In just the treated hearts treated with stem cells, small vessels characterized by irregular vessel walls were observed. The cerium anode X-ray system allowed visualization of microvessels in excised ischemic canine hearts, and may evaluate the effect of cardiac stem cell therapy. |
| Databáze: | OpenAIRE |
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