A Model of Hyperhomocysteine-Induced Endothelial Dysfunction in Rats
| Autor: | E. A. Konovalova, O. O. Novikov, Liliya V. Korokina, M. V. Korokin, V. A. Ragulina, Vladimir V. Gureev, Gudyrev Os, Lyudmila M. Danilenko, Mikhail V. Pokrovskiy, A. S. Belous, T. A. Denisyuk |
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| Rok vydání: | 2011 |
| Předmět: |
Hyperhomocysteinemia
Methionine Endothelium Homocysteine business.industry General Medicine Pharmacology medicine.disease General Biochemistry Genetics and Molecular Biology Rats chemistry.chemical_compound medicine.anatomical_structure chemistry medicine Animals Endothelium Vascular Vascular Diseases Vascular pathology Endothelial dysfunction business |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 152:213-215 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-011-1491-9 |
| Popis: | Intragastric methionine (3 g/kg daily for 7 days) elevates homocysteine concentration and increases the endothelial dysfunction coefficient. This protocol of methionine treatment is an adequate model of hyperhomocysteine-induced endothelial dysfunction and can be used for studies of the endothelio- and cardioprotective effects of drugs. |
| Databáze: | OpenAIRE |
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