Growth hormone and hematopoiesis: A retrospective analysis on a large cohort of children with growth hormone deficiency
| Autor: | Valentina Guarnotta, Maria Grazia Mineo, Carla Giordano, Alessandro Ciresi, S. Radellini, Giulia Piazza |
|---|---|
| Přispěvatelé: | Ciresi A, Piazza G, Radellini S, Guarnotta V, Mineo MG, Giordano C. |
| Rok vydání: | 2018 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Anemia Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Settore MED/13 - Endocrinologia Growth hormone deficiency 03 medical and health sciences 0302 clinical medicine Endocrinology Humans Growth hormone treatment Medicine Hematopoiesi Insulin-Like Growth Factor I Child Children Growth hormone Growth Disorders Retrospective Studies Human Growth Hormone business.industry Normocytic anemia medicine.disease Hematopoiesis Haematopoiesis Child Preschool 030220 oncology & carcinogenesis Erythropoiesis Female Hemoglobin business Hormone |
| Zdroj: | Growth Hormone & IGF Research. :8-13 |
| ISSN: | 1096-6374 |
| DOI: | 10.1016/j.ghir.2018.07.005 |
| Popis: | Objective: Few large-scale studies regarding the impact of GH deficiency (GHD) on hematopoiesis in children have been reported. Our aim was to investigate hematopoiesis indices in a large cohort of GHD children at diagnosis and during GH treatment (GHT) and any correlation with hormonal parameters. Design: Clinical and biochemical data of children with idiopathic GHD at diagnosis and annually up to 36 months of GHT were retrospectively evaluated. Overall, 255 children reached 12 months, 140 children 24 months and 86 children 36 months of follow-up during GHT. Results: At baseline, 18.4% of GHD children and 10.1% of controls showed normocytic anemia. GHD children showed lower hemoglobin (Hb) (p = 0.007), red blood cells (RBC) (p < 0.001) and hematocrit (Ht) (p = 0.001) than controls. During GHT, the percentage of anemic patients decreased from 18.4 to 5.4–3.5 and 4.6% after 12 (p = 0.001), 24 (p < 0.001) and 36 months (p < 0.001) of GHT, respectively. In both anemic and non-anemic patients, a significant increase in Hb (p < 0.001 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect