High TSH concentrations in 'euthyroidism': explanation based on control-loop theory
| Autor: | J S Beck, B. E. Storey, J. Crooks, T. E. Isles, T J Wilkin |
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| Rok vydání: | 1977 |
| Předmět: |
Adult
Male Thyroid Hormones endocrine system Psychosis medicine.medical_specialty Pituitary gland endocrine system diseases medicine.medical_treatment Thyroid Gland Thyrotropin Models Biological Feedback chemistry.chemical_compound Internal medicine Humans Medicine Euthyroid General Environmental Science Clinical Trials as Topic business.industry Lithium carbonate Thyroid General Engineering Thyroidectomy General Medicine Subtotal thyroidectomy Middle Aged medicine.disease Thyroid Diseases medicine.anatomical_structure Endocrinology chemistry Pituitary Gland General Earth and Planetary Sciences Female business Research Article Hormone |
| Zdroj: | BMJ. 1:993-996 |
| ISSN: | 1468-5833 0959-8138 |
| DOI: | 10.1136/bmj.1.6067.993 |
| Popis: | High concentrations of thyroid-stimulating hormone (TSH) in the serum have often been reported in apparently euthyroid patients with damaged thyroids. We have confirmed this finding in 14 patients 18 months after subtotal thyroidectomy for Graves's disease (group 1) and in 14 patients with manic-depressive psychosis (group 2) receiving lithium carbonate, which reduces thyroid reserve. One factor common to groups 1 and 2 but not to the controls was reduced thyroid reserve or functioning capacity, and, using established physical principles of servo-control, we have tried to define the mechanism. A series of curves were projected to indicate how TSH might be expected to vary with functioning thyroid capacity. |
| Databáze: | OpenAIRE |
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