| Popis: |
Corticotrophin preparations are capable of stimulating the phosphorylase activity of fresh beef adrenal extract. The effect disappears when the extract is heated or purified and decreases with increasing age of the extract. 5-adenosine monophosphate has no influence on the phosphorylase activity of fresh beef adrenal extract but has a stimulating effect when the preparation is dialyzed. By ammonium sulfate precipitation, calcium phosphate gel adsorption and ammonium sulfate fractionation, two phosphorylase fractions were obtained, one being influenced by 5-adenosine monophosphate to a much higher degree than the other one. None were influenced by corticotrophin. |
