Development of a new aerosol delivery system for systemic pulmonary delivery in anaesthetized and orotracheal intubated rats
| Autor: | Rosario Lizio, Wolfgang Jahn, Thomas Klenner, Thomas Nolte, Antonio W Sarlikiotis, Degenhard Marx, Claus-Michael Lehr, Gerrit Borchard |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Drug media_common.quotation_subject Biological Availability Common method Absorption (skin) Absorption Rats Sprague-Dawley Aerosol delivery Drug Delivery Systems Pharmacokinetics In vivo Administration Inhalation Intubation Intratracheal Animals Medicine Distribution (pharmacology) Lung media_common Aerosols General Veterinary business.industry respiratory system Rats Bioavailability Anesthesia Animal Science and Zoology business |
| Zdroj: | Laboratory Animals. 35:261-270 |
| ISSN: | 1758-1117 0023-6772 |
| DOI: | 10.1258/0023677011911589 |
| Popis: | Over the last decade, the systemic absorption of a broad range of therapeutics after pulmonary application has been demonstrated in animals as well as in humans. The most common method used in the laboratory is the intratracheal instillation of drugs in solution. This method is, however, unsatisfactory, because of discrepancies in particle distribution, clearance, kind of injury and bioavailability between instillation and inhalative application. On the other hand, a precise determination of the amount of drug applied by aerosol, and of the aerosol volume retained within the lungs is rather difficult, and is not possible for use with small animals such as mice or rats. We describe a system which allows the delivery of aerosols directly into the animal's lungs, and calculation of the amount of drug retained in the lungs. Our system was tested in vitro and in vivo and was shown to allow precise and efficient pharmacokinetic and toxicological studies to be carried out. |
| Databáze: | OpenAIRE |
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