The Controversy of Lateral Aberrant Thyroid and the use of BRAF Immunostain
| Autor: | Peter Angelos, Nicole A. Cipriani, Aaron Wallace |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Proto-Oncogene Proteins B-raf Pathology medicine.medical_specialty endocrine system diseases Pathology and Forensic Medicine Metastasis Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine medicine Humans Thyroid Neoplasms 030223 otorhinolaryngology Retrospective Studies business.industry Thyroid medicine.disease Lateral neck Carcinoma Papillary medicine.anatomical_structure Cervical lymph nodes Lymphatic Metastasis 030220 oncology & carcinogenesis Aberrant thyroid Immunohistochemistry Female Surgery Lymph Nodes Anatomy business Immunostaining |
| Zdroj: | International Journal of Surgical Pathology. 30:217-220 |
| ISSN: | 1940-2465 1066-8969 |
| Popis: | A 29-year-old women presents with primary intrathyroidal papillary thyroid carcinoma (BRAF VE1 positive) with morphologically recognizable metastases to cervical lymph nodes (BRAF VE1 positive) as well as a focus of bland-appearing thyroid follicles within the capsule of a level II lymph node (BRAF VE1 negative). There exist various theories regarding the possible developmental origins of “benign” intranodal thyroid tissue in the lateral neck. While the true nature of the bland follicles may not be definitively resolved in this case, these findings are suggestive that they do not represent metastasis from the main papillary thyroid carcinoma. Additional insight into this unusual phenomenon may be gathered by more specific clonal analysis of these microscopic foci. |
| Databáze: | OpenAIRE |
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