Cross-correlated relaxation rates provide facile exchange signature in selectively labeled RNA

Autor:	Kehinde M, Taiwo, Hyeyeon, Nam, Regan M, LeBlanc, Andrew P, Longhini, Theodore K, Dayie
Rok vydání:	2022
Předmět:	Nuclear and High Energy Physics Magnetic Resonance Spectroscopy Biophysics Humans Proteins RNA Condensed Matter Physics Nuclear Magnetic Resonance Biomolecular Biochemistry
Zdroj:	Journal of Magnetic Resonance. 342:107245
ISSN:	1090-7807
Popis:	Gerhard Wagner has made numerous contributions to NMR spectroscopy, particularly his developments in the field of spin-relaxation stand out in directly mapping the spectral density functions of proteins. He and his group developed experimental techniques to reveal the importance of dynamics to protein biological function and drug discovery. On his 75th birthday, we take this opportunity to highlight how some of those seminal ideas developed for proteins are being extended to RNAs. The role of dynamics in the structure and function of RNA has been a major interest in drug design and therapeutics. Here we present the use of cross-correlated relaxation rates (η
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3561127753f1f7d87259beabbf566735 https://doi.org/10.1016/j.jmr.2022.107245 Zobrazit plný text záznamu Full Text from ScienceDirect