Distinct effects of rs895819 on risk of different cancers: an update meta-analysis
| Autor: | Guangdi Chen, Xinkai Wu, Wenpan Fang, Muxiong Chen, Yu Weng, Liqin Lu, Suchen Bian |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
genetic variant
0301 basic medicine medicine.medical_specialty miR-27a Colorectal cancer business.industry Public health Odds ratio cancer risk Esophageal cancer medicine.disease Confidence interval 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Breast cancer Oncology 030220 oncology & carcinogenesis Meta-analysis Internal medicine medicine Lung cancer business Meta-Analysis |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.17454 |
| Popis: | // Muxiong Chen 1, 2, * , Wenpan Fang 1, 3, * , Xinkai Wu 1 , Suchen Bian 1 , Guangdi Chen 1, 3 , Liqin Lu 4 and Yu Weng 5 1 Institute of Environmental Health, Zhejiang University School of Medicine, Hangzhou, China 2 Research Center of Molecular Medicine, Zhejiang University School of Medicine, Hangzhou, China 3 Department of Public Health, Zhejiang University School of Medicine, Hangzhou, China 4 Department of Oncology, Zhejiang Provincial People’s Hospital, Hangzhou, China 5 Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China * These authors contributed equally to this work Correspondence to: Yu Weng, email: wengyu1121@163.com Liqin Lu, email: luliqin@yeah.net Guangdi Chen, email: chenguangdi@zju.edu.cn Keywords: miR-27a, genetic variant, cancer risk, meta-analysis Received: January 26, 2017 Accepted: April 12, 2017 Published: April 27, 2017 ABSTRACT Previous studies have indicated an association between the genetic variant in pre-miR-27a rs895819 with A->G transition and cancer risk; however, the results remain inconsistent and somehow conflicting in different cancers. Therefore, to obtain a more reliable conclusion, we performed an update meta-analysis by searching PubMed database or other databases. Odds ratio (ORs) and 95% confidence interval (CIs) were calculated to evaluate cancer risk. A total of 34 case-control studies involving 15,388 cases and 18,704 controls were included. The results showed that rs895819 was associated with an increased cancer risk (GG vs. AA/AG: OR = 1.15, 95% CI = 1.02–1.29). Furthermore, stratification analyses revealed an association of rs895819 with increased cancer risk among Asians (GG vs. AA: OR = 1.17, 95% CI = 1.01–1.36; GG vs. AA/AG: OR = 1.18, 95% CI = 1.03–1.35), but not Caucasians. Interestingly, the [G] allele of rs895819 was significantly associated with decreased risk of breast cancer (G vs. A: OR = 0.91, 95% CI = 0.86–0.97). However, rs895819 was associated with increased risk of colorectal cancer (GG vs. AA: OR = 1.56, 95% CI = 1.31–1.85; GG vs. AA/AG: OR = 1.53, 95% CI = 1.30–1.79; G vs. A: OR = 1.19, 95% CI = 1.09–1.30) and lung cancer (GG vs. AA/AG: OR = 1.43, 95% CI = 1.00–2.04). In addition, no association was found between rs895819 and risk of gastric cancer or esophageal cancer. In conclusion, our findings suggest distinct effects of rs895819 on risk of different cancers, and future well-designed studies with large samples are required to further validate our results. |
| Databáze: | OpenAIRE |
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