Synthesis and biological activity of 21,22-cyclosteroids and their derivatives

Autor:	Maryia V. Barysevich, Marharyta V. Laktsevich-Iskryk, Alexander M. Scherbakov, Diana I. Salnikova, Olga E. Andreeva, Danila V. Sorokin, Yuri Y. Shchegolev, Alaksiej L. Hurski, Vladimir N. Zhabinskii, Vladimir A. Khripach
Rok vydání:	2021
Předmět:	Pharmacology Male Organic Chemistry Clinical Biochemistry Imidazoles Breast Neoplasms Antineoplastic Agents Biochemistry Endocrinology Receptors Androgen Cell Line Tumor Pregnenolone Humans Cyclosteroids Steroids Molecular Biology Cell Proliferation
Zdroj:	Steroids. 188
ISSN:	1878-5867
Popis:	Synthesis of 21,22-cyclosteroids has been achieved starting from pregnenolone acetate. The key transformation was the Kulinkovich reaction of 17-vinyl steroids with esters. The resulting cyclopropanols were further subjected to three-membered ring-opening under various conditions including to base-, palladium or visible light-promoted isomerization and cross-coupling reaction. A number of steroidal Δ
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355a5b3513399b2d1812510516e37219 https://pubmed.ncbi.nlm.nih.gov/36336105 Zobrazit plný text záznamu Full Text from ScienceDirect