Organization of the reach and grasp in head-fixed vs freely-moving mice provides support for multiple motor channel theory of neocortical organization
| Autor: | Jessica R. Kuntz, Mukt Patel, Ian Q. Whishaw, Majid H. Mohajerani, Behroo Mirza Agha, Jamshid Faraji, Gerlinde A. S. Metz |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Reach and grasp Head (linguistics) Food item Neocortex Motor Activity 03 medical and health sciences Mice 0302 clinical medicine Animals Communication Behavior Animal business.industry General Neuroscience GRASP Mice Inbred C57BL 030104 developmental biology Action (philosophy) business Psychology Neuroscience Head 030217 neurology & neurosurgery Psychomotor Performance Communication channel |
| Zdroj: | Experimental brain research. 235(6) |
| ISSN: | 1432-1106 |
| Popis: | Multiple motor channel (MMC) theory of neocortical organization proposes that complex movements, such as reaching for a food item to eat, are produced by the coordinated action of separate neural channels. For example, the human reach-to-grasp act is mediated by two visuo-parieto-motor cortex channels, one for the reach and one for the grasp. The present analysis asked whether there is a similar organization of reach-and-grasp movements in the mouse. The reach-to-eat movements of the same mice were examined from high-shutter speed, frame-by-frame video analysis in three tasks in which the mice obtained equivalent success scores: when freely-moving reaching for food pellets, when head-fixed reaching for food pellets, and when head-fixed reaching for pieces of pasta. To reach, the mice used egocentric cues to vary upper arm movements in a task-appropriate manner to place an open hand on the food or to locate the food using a “touch-release-grasp” strategy. Although mice could not hand-shape offline when reaching, they could hand-shape using online touch-related cues from the mouth to manipulate the food at the mouth. That the reach can be performed offline in relation to egocentric cues whereas hand shaping for the grasp requires online cues supports the idea that for the mouse, as for primates, the reach and grasp are separate acts. The results are further discussed in relation to the use of the head-fixed behavioral procedure to identify the independent neural substrates of the reach and the grasp using mesoscale stimulation/imaging methods. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink