Memory and depressive effect on male and female Swiss mice exposed to tannery effluent
| Autor: | Guilherme Malafaia, Abraão Tiago Batista Guimarães, Aline Sueli de Lima Rodrigues, Raíssa de Oliveira Ferreira |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.drug_class Industrial Waste Physiology Anxiety 010501 environmental sciences Toxicology 01 natural sciences Tannery effluents Anxiolytic Mice 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Developmental Neuroscience Animals Medicine Effluent 0105 earth and related environmental sciences Memory Disorders Behavior Animal Depression business.industry Neurotoxicity medicine.disease chemistry Anxiogenic Female medicine.symptom business Xenobiotic 030217 neurology & neurosurgery Behavioural despair test |
| Zdroj: | Neurotoxicology and Teratology. 61:123-127 |
| ISSN: | 0892-0362 |
| Popis: | Although tannery industries generate substantial profits to the countries they are located in, they work with one of the most environmentally harmful human activities. Tannery effluents (TE) are highly toxic; thus, their improper release into water bodies may cause severe problems to individuals depending on this water. Therefore, the aim of the current study is to assess the effects of oral exposure to TE on the anxiety-, memory deficit- and depression-predictive behaviors in male and female Swiss adult mice. The following experimental groups were set in order to do so, control, positive control (reference drugs) and effluent. The animals in the effluent group were treated with 5% TE diluted in potable water for 15 consecutive days. The neurobehavioral tests started on the 12th experimental day. The results found through the elevated plus-maze test (for anxiety prediction) showed no anxiogenic or anxiolytic effects on animals exposed to TE. On the other hand, animals treated with TE showed short- and long-term memory deficit in the object recognition test, as well as depression-predictive behavior in the forced swimming test. These results may concern the high concentration of heavy metals and neurotoxic organic compounds in the TE. Therefore, the oral exposure to TE, even for a short period-of-time, has effects on the central nervous system (CNS) that lead to neurobehavioral changes. Thus, the current study broadens the knowledge on this research field by demonstrating the neurotoxicity of xenobiotics to male and female Swiss mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect