Quantitative measurements of regional lung ventilation using helium3 MRI in a metacholine-induced bronchoconstriction model

Autor: Vasile Stupar, David Dupuich, Yannick Crémillieux, Emmanuelle Canet, Patrice Adeleine, Karim Mosbah, Chantal Nemoz, Yves Berthezène
Přispěvatelé: Laboratoire Creatis, Compte Général, Biostatistiques santé, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Résonance Magnétique Nucléaire (RMN), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Male
Time Factors
[SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging
[SDV]Life Sciences [q-bio]
[INFO.INFO-IM] Computer Science [cs]/Medical Imaging
Helium
01 natural sciences
030218 nuclear medicine & medical imaging
Bronchoconstrictor Agents
Rats
Sprague-Dawley
0302 clinical medicine
[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing
Image Processing
Computer-Assisted
Lung
Methacholine Chloride
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
Inhalation
Magnetic Resonance Imaging
[PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
[SPI.ELEC]Engineering Sciences [physics]/Electromagnetism
medicine.anatomical_structure
[INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV]
Anesthesia
[INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV]
Breathing
[PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph]
Bronchoconstriction
[SDV.IB]Life Sciences [q-bio]/Bioengineering
medicine.symptom
[PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
medicine.drug
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT]
[INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing
[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine
Mri studies
[SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine
Magnetics
03 medical and health sciences
Animal model
0103 physical sciences
medicine
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging
Animals
Radiology
Nuclear Medicine and imaging
010306 general physics
Lung ventilation
[SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing
[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph]
[SDV.IB] Life Sciences [q-bio]/Bioengineering
[SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph]
Models
Statistical
[PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph]
business.industry
Lasers
[SPI.ELEC] Engineering Sciences [physics]/Electromagnetism
Rats
[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging
[SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic
Methacholine
Nuclear medicine
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: Journal of magnetic resonance imaging
Journal of magnetic resonance imaging, 2006, 24, pp.611-616
Journal of Magnetic Resonance Imaging
Journal of Magnetic Resonance Imaging, Wiley-Blackwell, 2006, 24, pp.611-616. ⟨10.1002/jmri.20671⟩
J Magn Reson Imaging
J Magn Reson Imaging, 2006, 24 (3), pp.611-616
Journal of Magnetic Resonance Imaging, 2006, 24, pp.611-616. ⟨10.1002/jmri.20671⟩
ISSN: 1053-1807
1522-2586
DOI: 10.1002/jmri.20671⟩
Popis: Purpose To demonstrate ventilation changes in an animal model of methacholine-induced bronchoconstriction using hyperpolarized (HP) helium-3 (He-3) MRI. Materials and Methods Bronchoconstriction was induced in 11 healthy rats using an intravenous injection of methacholine. The He-3 was laser-polarized using a custom-built system. MRI studies were performed on a 2-Tesla bore magnet. Coronal dynamic ventilation images were obtained using a single inhalation of the laser-polarized He-3 gas before and after methacholine injection. Ventilation image series were processed on a pixel-by-pixel basis to generate three regional ventilation parameters: gas flow rate, filling time, and maximum gas volume. Student's paired t-test was used for analysis. Results Ventilation image series with a temporal resolution of 5 msec were obtained before and after methacholine challenge. Quantitative regional gas dynamic information demonstrated statistically significant differences between the baseline and constricted states. Following methacholine injection, the mean flow values were significantly lower for the right lung (RL) (P = 0.006) and left lung (LL) (P = 0.024), while the mean filling time was found to be greater (RL: P = 0.08, LL: P = 0.021). Gas volume values at maximum inspiration were found to be significantly lower after methacholine (RL: P = 0.002; LL: P = 0.036). Conclusion He-3 MRI demonstrated and quantified regional ventilation changes in bronchoconstriction conditions in rats. J. Magn. Reson. Imaging 2006. © 2006 Wiley-Liss, Inc.
Databáze: OpenAIRE
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