Saturation biopsy protocol enhances prediction of pT3 and surgical margin status on prostatectomy specimen
| Autor: | René Yiou, Dimitri Vordos, Alexandre de la Taille, Stéphane Larré, Stephanie Chemama, Laurent Salomon, Yves Allory, Aurélien Descazeaud, Dominique Chopin, Claude C. Abbou, Andras Hoznek, Mark A. Rubin |
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| Rok vydání: | 2006 |
| Předmět: |
Nephrology
Male medicine.medical_specialty Surgical margin Urology medicine.medical_treatment Biopsy Severity of Illness Index Prostate cancer Prostate Internal medicine medicine Humans cardiovascular diseases Aged Neoplasm Staging Retrospective Studies Postoperative Care Prostatectomy medicine.diagnostic_test business.industry fungi Area under the curve Prostatic Neoplasms Middle Aged medicine.disease Prognosis Surgery medicine.anatomical_structure nervous system ROC Curve Positive Surgical Margin business circulatory and respiratory physiology Follow-Up Studies |
| Zdroj: | World journal of urology. 24(6) |
| ISSN: | 0724-4983 |
| Popis: | A 21-samples saturation biopsy procedure (SBP) was developed in order to improve prostate cancer detection rate. Out of 650 patients who underwent this protocol, 150 had a clinically localized prostate cancer and underwent a radical prostatectomy. The number of cores positive for tumor was assessed in the SBP, and also in the sextant component of the SBP (SC) and in the non-sextant component of the SBP (NSC). Numbers of cores positive for tumor on SBP, SC, and NSC were significantly higher in pT3 group versus pT2 (P < 0.001 each) and in positive surgical margins (PSM) group versus no PSM (P < 0.001 each). When comparing area under the curve obtained from SBP with those obtained from NSC and SC, the SBP showed higher accuracy than the NSC and the SC for the prediction of pT3 and PSM. On multivariate analyses, SC and NSC were independent predictors of pT3 and PSM on radical prostatectomy. |
| Databáze: | OpenAIRE |
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