Increased Conversion of Tryptophan to Nicotinamide in Rats by Dietary Valproate
| Autor: | Rina Kondo, Mitsue Sano, Tsutomu Fukuwatari, Katsumi Shibata |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Niacinamide Vitamin medicine.medical_specialty medicine.medical_treatment 3-Hydroxyanthranilic Acid Administration Oral Applied Microbiology and Biotechnology Biochemistry Analytical Chemistry chemistry.chemical_compound Internal medicine medicine Animals Rats Wistar Molecular Biology Chromatography High Pressure Liquid Food Formulated chemistry.chemical_classification Valproic Acid Dose-Response Relationship Drug Nicotinamide Organic Chemistry Tryptophan Fatty acid General Medicine Quinolinic Acid Rats Anticonvulsant Endocrinology Liver chemistry lipids (amino acids peptides and proteins) NAD+ kinase Biotechnology Quinolinic acid medicine.drug |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 77:295-300 |
| ISSN: | 1347-6947 0916-8451 |
| DOI: | 10.1271/bbb.120716 |
| Popis: | Valproic acid (VPA) is a short-chained, branched fatty acid that is widely used in humans as an anticonvulsant and mood stabilizer, and has been reported to increase the liver NAD concentration. We investigated the effects of VPA on the conversion of tryptophan to nicotinamide. Rats were fed diets containing various amounts of VPA (0, 0.5, and 1.0% in the diets) for 14 d, 24-h urine samples were collected, and tryptophan and its catabolites were measured. We found that the conversion of tryptophan to nicotinamide was increased by feeding a diet containing VPA (p |
| Databáze: | OpenAIRE |
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