Loganin Attenuates the Severity of Acute Kidney Injury Induced by Cisplatin through the Inhibition of ERK Activation in Mice
| Autor: | Joon Yeon Shin, Ji-Won Choi, Ziqi Zhou, Dong-Gu Kim, Ho-Joon Song, Sung-Joo Park, Dong-Uk Kim, Bitna Kweon, Ho Sub Lee, Gi-Sang Bae |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
MAP Kinase Signaling System medicine.medical_treatment Intraperitoneal injection cisplatin Pharmacology Kidney Catalysis Article Nephrotoxicity Blood Urea Nitrogen Inorganic Chemistry lcsh:Chemistry erk chemistry.chemical_compound Mice medicine Animals Iridoids Physical and Theoretical Chemistry loganin Molecular Biology Blood urea nitrogen lcsh:QH301-705.5 Spectroscopy Cisplatin Creatinine Cell Death Loganin business.industry Organic Chemistry Acute kidney injury apoptosis General Medicine medicine.disease ferroptosis Computer Science Applications Mice Inbred C57BL chemistry lcsh:Biology (General) lcsh:QD1-999 acute kidney injury Cytokines Tumor necrosis factor alpha business medicine.drug |
| Zdroj: | International Journal of Molecular Sciences Volume 22 Issue 3 International Journal of Molecular Sciences, Vol 22, Iss 1421, p 1421 (2021) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22031421 |
| Popis: | Cisplatin is the most widely used chemotherapeutic agent. However, it often causes nephrotoxicity, which results in acute kidney injury (AKI). Therefore, we urgently need a drug that can reduce the nephrotoxicity induced by cisplatin. Loganin is a major iridoid glycoside isolated from Corni fructus that has been used as an anti-inflammatory agent in various pathological models. However, the renal protective activity of loganin remains unclear. In this study, to examine the protective effect of loganin on cisplatin-induced AKI, male C57BL/6 mice were orally administered with loganin (1, 10, and 20 mg/kg) 1 h before intraperitoneal injection of cisplatin (10 mg/kg) and sacrificed at three days after the injection. The administration of loganin inhibited the elevation of blood urea nitrogen (BUN) and creatinine (CREA) in serum, which are used as biomarkers of AKI. Moreover, histological kidney injury, proximal tubule damages, and renal cell death, such as apoptosis and ferroptosis, were reduced by loganin treatment. Also, pro-inflammatory cytokines, such as interleukin (IL)-1&beta IL-6, and tumor necrosis factor (TNF)-&alpha reduced by loganin treatment. Furthermore, loganin deactivated the extracellular signal-regulated kinases (ERK) 1 and 2 during AKI. Taken together, our results suggest that loganin may attenuate cisplatin-induced AKI through the inhibition of ERK1/2. |
| Databáze: | OpenAIRE |
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