Antihypertensive effect of biotin in stroke-prone spontaneously hypertensive rats
| Autor: | Kimiko Horiuchi, Kousaku Ohinata, Michio Komai, Yuji Furukawa, Shin Kamiyama, Mari Watanabe-Kamiyama, Hitoshi Shirakawa |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Vitamin
Male medicine.medical_specialty Medicine (miscellaneous) Biotin deficiency Biotin Rats Inbred WKY Time chemistry.chemical_compound Insulin resistance Spontaneously hypertensive rat Internal medicine Quinoxalines Rats Inbred SHR medicine Animals Genetic Predisposition to Disease Stroke Glucose tolerance test Oxadiazoles Nutrition and Dietetics medicine.diagnostic_test business.industry Vitamins Glucose Tolerance Test medicine.disease Coronary Vessels Rats Endocrinology Blood pressure NG-Nitroarginine Methyl Ester chemistry Guanylate Cyclase Hypertension Nitric Oxide Synthase business |
| Zdroj: | The British journal of nutrition. 99(4) |
| ISSN: | 0007-1145 |
| Popis: | Biotin is a member of the vitamin B-complex family. Biotin deficiency has been associated with hyperglycaemia and insulin resistance in animals and humans. In the present study, we investigated the pharmacological effects of biotin on hypertension in the stroke-prone spontaneously hypertensive rat (SHRSP) strain. We observed that long-term administration of biotin decreased systolic blood pressure in the SHRSP strain; also, a single dose of biotin immediately decreased systolic blood pressure in this strain. Pretreatment with the guanylate cyclase inhibitor 1H-[1,2,4]oxadiazole [4,3-α]quinoxalin-1-one abolished the hypotensive action of biotin in the SHRSP strain, while pretreatment with the NO synthase inhibitorNG-nitro-l-arginine methyl ester had no effect on the action of biotin. Biotin reduced coronary arterial thickening and the incidence of stroke in the SHRSP strain. These results suggest that the pharmacological dose of biotin decreased the blood pressure of the SHRSPviaan NO-independent direct activation of soluble guanylate cyclase. Our findings reveal the beneficial effects of biotin on hypertension and the incidence of stroke. |
| Databáze: | OpenAIRE |
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