Maximum tolerated doses and erythropoiesis effects in the mouse bone marrow by 79 pesticides’ technical materials assessed with the micronucleus assay
| Autor: | Marina Goumenou, Yulia A. Revazova, Aristidis Tsatsakis, Valerii N. Rakitskii, N. S. Averianova, Alexander I. Vardavas, Polychronis Stivaktakis, Gleb V. Masaltsev, Nataliya A. Ilyushina, Olga Dmitricheva |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
mg/kg b.w.
milligram per kilogram of body weight Health Toxicology and Mutagenesis 010501 environmental sciences Pharmacology CI confidence interval of the mean Toxicology 01 natural sciences Article Mice 03 medical and health sciences 0302 clinical medicine Maximum tolerated doses lcsh:RA1190-1270 MN test micronucleus test Micronucleus test medicine Erythropoiesis Pesticides Inhibitory effect ComputingMethodologies_COMPUTERGRAPHICS 0105 earth and related environmental sciences lcsh:Toxicology. Poisons PCE polychromatic erythrocyte business.industry MTD maximum tolerated dose Triazoles Pesticide NCE normochromatic erythrocyte medicine.anatomical_structure Es total erythrocytes Toxicity Bone marrow business Micronucleus 030217 neurology & neurosurgery Target organ |
| Zdroj: | Toxicology Reports, Vol 6, Iss, Pp 105-110 (2019) Toxicology Reports |
| ISSN: | 2214-7500 |
| Popis: | Graphical abstract Highlights • Triazole pesticides exert an inhibitory effect on erythropoiesis in mammal bone marrow. • The effects of triazole pesticides may depend on the type and arrangement of substituents in molecules. • At the lower acceptable level of PCEs/(PCEs + NCEs) (20%) suppression of erythropoiesis masks cytogenetic effects. • The MTDs of 79 different technical materials of pesticide active ingredients for CD-1 mice have been determined. Effects of technical materials of pesticide active ingredients, belonging to various chemical classes, on erythropoiesis in mouse bone marrow were studied as part of the research on the pesticide mutagenic activity in micronucleus test. The purpose of the present study was to estimate the toxic action of the test substances on the target organ and the validity of the results of the micronucleus assay under conditions of erythropoiesis suppression. It was demonstrated that intragastrically administrated triazole pesticides reached bone marrow (target organ where micronucleus induction was assessed) and exerted an inhibitory effect on erythropoiesis. The effects of triazole pesticides were enhanced in the following order: difenoconazole ≤ tebuconazole |
| Databáze: | OpenAIRE |
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