Phenotypic plasticity within yeast colonies: differential partitioning of cell fates
| Autor: | Tamas Kapros, Sarah Piccirillo, Saul M. Honigberg |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genetics Phenotypic plasticity Cell type Microscopy Confocal integumentary system biology 030106 microbiology Saccharomyces cerevisiae Cell General Medicine Spores Fungal biology.organism_classification Article Yeast 03 medical and health sciences Multicellular organism 030104 developmental biology medicine.anatomical_structure Meiosis medicine Ploidy |
| Zdroj: | Current Genetics. 62:467-473 |
| ISSN: | 1432-0983 0172-8083 |
| Popis: | Across many phyla, a common aspect of multicellularity is the organization of different cell types into spatial patterns. In the budding yeast Saccharomyces cerevisiae, after diploid colonies have completed growth, they differentiate to form alternating layers of sporulating cells and feeder cells. In the current study, we found that as yeast colonies developed, the feeder cell layer was initially separated from the sporulating cell layer. Furthermore, the spatial pattern of sporulation in colonies depended on the colony's nutrient environment; in two environments in which overall colony sporulation efficiency was very similar, the pattern of feeder and sporulating cells within the colony was very different. As noted previously, under moderately suboptimal conditions for sporulation-low acetate concentration or high temperature-the number of feeder cells increases as does the dependence of sporulation on the feeder-cell transcription factor, Rlm1. Here we report that even under a condition that is completely blocked sporulation, the number of feeder cells still increased. These results suggest broader implications to our recently proposed "Differential Partitioning provides Environmental Buffering" or DPEB hypothesis. |
| Databáze: | OpenAIRE |
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