Association of apolipoprotein E polymorphism in late-onset Alzheimer's disease and vascular dementia in Brazilians
| Autor: | Júlia K. Hotta, D. R. S. Souza, Waldir Antonio Tognola, Antonio Carlo Batalini Brandão, S. Pinheiro Júnior, Eloiza H. Tajara, J.E. Dos Santos, M.R. De Godoy |
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| Přispěvatelé: | Faculdade de Medicina de São José do Rio Preto (FAMERP), Universidade de São Paulo (USP), Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Apolipoprotein E
Male Aging Physiology Disease Biochemistry Polymerase Chain Reaction Vascular dementia law.invention law Risk Factors Genotype General Pharmacology Toxicology and Pharmaceutics lcsh:QH301-705.5 Polymerase chain reaction Genetics Aged 80 and over lcsh:R5-920 education.field_of_study General Neuroscience General Medicine Alzheimer's disease lipids (amino acids peptides and proteins) Female lcsh:Medicine (General) Immunology Population Biophysics Genetic polymorphisms Apolipoproteins E Alzheimer Disease medicine Humans Genetic Predisposition to Disease Allele education Alleles Aged Polymorphism Genetic business.industry Dementia Vascular Cell Biology medicine.disease Genotype frequency lcsh:Biology (General) Case-Control Studies Dementia business |
| Zdroj: | SciELO Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Brazilian Journal of Medical and Biological Research, Vol 36, Iss 7, Pp 919-923 (2003) Brazilian Journal of Medical and Biological Research, Volume: 36, Issue: 7, Pages: 919-923, Published: JUL 2003 |
| ISSN: | 0100-879X |
| Popis: | Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:52:41Z No. of bitstreams: 1 S0100-879X2003000700013.pdf: 495009 bytes, checksum: 24379cf1c394dc9e3fd0edd5f8c0da2e (MD5) Made available in DSpace on 2013-08-22T18:52:41Z (GMT). No. of bitstreams: 1 S0100-879X2003000700013.pdf: 495009 bytes, checksum: 24379cf1c394dc9e3fd0edd5f8c0da2e (MD5) Previous issue date: 2003-07-01 Made available in DSpace on 2013-09-30T19:44:07Z (GMT). No. of bitstreams: 2 S0100-879X2003000700013.pdf: 495009 bytes, checksum: 24379cf1c394dc9e3fd0edd5f8c0da2e (MD5) S0100-879X2003000700013.pdf.txt: 17885 bytes, checksum: 3ee324e6f6129bd62d9c0c114ab3a6d2 (MD5) Previous issue date: 2003-07-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:11:33Z No. of bitstreams: 2 S0100-879X2003000700013.pdf: 495009 bytes, checksum: 24379cf1c394dc9e3fd0edd5f8c0da2e (MD5) S0100-879X2003000700013.pdf.txt: 17885 bytes, checksum: 3ee324e6f6129bd62d9c0c114ab3a6d2 (MD5) Made available in DSpace on 2014-05-20T15:11:33Z (GMT). No. of bitstreams: 2 S0100-879X2003000700013.pdf: 495009 bytes, checksum: 24379cf1c394dc9e3fd0edd5f8c0da2e (MD5) S0100-879X2003000700013.pdf.txt: 17885 bytes, checksum: 3ee324e6f6129bd62d9c0c114ab3a6d2 (MD5) Previous issue date: 2003-07-01 The genetic basis for dementias is complex. A common polymorphism in the apolipoprotein E (APOE) gene is considered to be the major risk factor in families with sporadic and late-onset Alzheimer's disease as well as in the general population. The distribution of alleles and genotypes of the APOE gene in late-onset Alzheimer's disease (N = 68), other late-life dementias (N = 39), and in cognitively normal controls (N = 58) was determined, as also was the risk for Alzheimer's disease associated with the epsilon4 allele. Peripheral blood samples were obtained from a total of 165 individuals living in Brazil aged 65-82 years. Genomic DNA was amplified by the polymerase chain reaction and the products were digested with HhaI restriction enzyme. APOE epsilon2 frequency was considerably lower in the Alzheimer's disease group (1%), and the epsilon3 allele and epsilon3/epsilon3 genotype frequencies were higher in the controls (84 and 72%, respectively) as were the epsilon4 allele and epsilon3/epsilon4 genotype frequencies in Alzheimer's disease (25 and 41%, respectively). The higher frequency of the epsilon4 allele in Alzheimer's disease confirmed its role as a risk factor, while epsilon2 provided a weak protection against development of the disease. However, in view of the unexpectedly low frequency of the epsilon4 allele, additional analyses in a more varied Brazilian sample are needed to clarify the real contribution of apolipoprotein E to the development of Alzheimer's disease in this population. Faculdade de Medicina de São José do Rio Preto (FAMERP) Departamento de Biologia Molecular Faculdade de Medicina de São José do Rio Preto (FAMERP) Departamento de Ciências Neurológicas Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Departamento de Clínica Médica Universidade Estadual Paulista Júlio de Mesquita Filho Departamento de Biologia Universidade Estadual Paulista Júlio de Mesquita Filho Departamento de Biologia |
| Databáze: | OpenAIRE |
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