Temperature-sensitive liposomes for co-delivery of tamoxifen and imatinib for synergistic breast cancer treatment
| Autor: | Kunal Manoj Ninave, Venkata Vamsi Krishna Venuganti, Anup Jose, Sriravali Karnam |
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| Rok vydání: | 2018 |
| Předmět: |
Drug
1 2-Dipalmitoylphosphatidylcholine Cell Survival Drug Compounding media_common.quotation_subject Pharmaceutical Science Antineoplastic Agents Breast Neoplasms 02 engineering and technology 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breast cancer Cell Line Tumor medicine Humans skin and connective tissue diseases media_common Liposome Chemistry Temperature Lysophosphatidylcholines Imatinib 021001 nanoscience & nanotechnology medicine.disease Drug Liberation Tamoxifen Imatinib mesylate Liposomes Imatinib Mesylate Cancer research Nanoparticles Female Nanocarriers Growth inhibition 0210 nano-technology medicine.drug |
| Zdroj: | Journal of Liposome Research. 29:153-162 |
| ISSN: | 1532-2394 0898-2104 |
| Popis: | Co-delivery of chemotherapeutic agents using nanocarriers is a promising strategy for enhancing therapeutic efficacy of anticancer agents. The aim of this work was to develop tamoxifen and imatinib dual drug loaded temperature-sensitive liposomes to treat breast cancer. Liposomes were prepared using 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), monopalmitoyl-2-hydroxy-sn-glycero-3-phosphocholine (MPPC), and different surface active agents. The liposomes were characterized for the average particle size, zeta potential, transition temperature, and drug release below and above liposomal transition temperature. The temperature-sensitive liposomes co-encapsulated with tamoxifen and imatinib were investigated for their synergistic activity against MCF-7 and MDA-MB-231 breast cancer cells. The liposomal nanoparticles showed a transition temperature of 39.4 °C and >70% encapsulation efficiency for tamoxifen and imatinib. The temperature-responsive liposomes showed more than 80% drug released within 30 min above transition temperature. Dual drug loaded liposomes showed synergistic growth inhibition against MCF-7 and MDA-MB-231 breast cancer cells. Co-delivery of tamoxifen and imatinib using temperature-sensitive liposomes can be developed as a potential targeting strategy against breast cancer. |
| Databáze: | OpenAIRE |
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