Cyclopropyl Scaffold: A Generalist for Marketed Drugs
| Autor: | Weyland Cheng, Meng-Yu Ba, Hai-Liang Zhu, Moran Sun, Yongtao Duan, Hong-Liang Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cyclopropanes
Pharmacology Drug Scaffold business.industry Therapeutic treatment media_common.quotation_subject Drug Evaluation Preclinical Hepacivirus General Medicine Disease Viral Nonstructural Proteins Gram-Positive Bacteria Urogenital diseases Bioinformatics Anti-Bacterial Agents Organic molecules Ciprofloxacin Gram-Negative Bacteria Drug Discovery Humans Medicine business Oligopeptides media_common |
| Zdroj: | Mini-Reviews in Medicinal Chemistry. 21:150-170 |
| ISSN: | 1389-5575 |
| Popis: | In recent decades, much attention has been given to cyclopropyl scaffolds, which commonly exist in natural products and synthetic organic molecules. Clinical drug molecules with cyclopropyl rings are an area of focus in therapeutic research due to their interesting chemical properties and unique pharmacology activity. These molecular drugs against different targets are applicable in some therapeutic treatment fields including cancer, infection, respiratory disorder, cardiovascular and cerebrovascular diseases, dysphrenia, nervous system disorders, endocrine and metabolic disorders, skin disease, digestive disorders, urogenital diseases, otolaryngological and dental diseases, and eye diseases. This review is a guide for pharmacologists who are in search of valid preclinical/clinical drug compounds where the progress, from 1961 to the present day, of approved marketed drugs containing cyclopropyl scaffold is examined. |
| Databáze: | OpenAIRE |
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