Occurrence of hepatitis in an elderly woman during the treatment of pembrolizumab for right advanced renal pelvis, ureteral cancer, and bladder cancer
| Autor: | Reina Sasaki, Shini Kanezawa, Kazushige Nirei, Yoichiro Yamana, Taku Mizutani, Hiroaki Yamagami, Ryota Masuzaki, Shinya Asatani, Mitsuhiko Moriyama, Mariko Kumagawa, Tomohiro Kaneko, Tomotaka Ishii, Masayuki Honda, Tatsuo Kanda, Hiroshi Takahashi, Naoki Matsumoto |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Urology Case Report RC799-869 Pembrolizumab 03 medical and health sciences 0302 clinical medicine medicine hepatitis In patient Hepatitis Bladder cancer Hepatology business.industry steroid Gastroenterology renal pelvis and ureteral cancer Metastatic liver disease Diseases of the digestive system. Gastroenterology Ureteral cancer medicine.disease medicine.anatomical_structure 030220 oncology & carcinogenesis Prednisolone 030211 gastroenterology & hepatology pembrolizumab medicine.symptom business immune‐related adverse event Renal pelvis medicine.drug |
| Zdroj: | JGH Open, Vol 5, Iss 6, Pp 722-724 (2021) JGH Open: An Open Access Journal of Gastroenterology and Hepatology |
| ISSN: | 2397-9070 |
| DOI: | 10.1002/jgh3.12554 |
| Popis: | Recently, the use of immune checkpoint inhibitors (ICIs) with or without chemotherapeutic agents has been increasing in the treatment for advanced cancer. Here, we report the occurrence of liver failure after the use of pembrolizumab in an 82‐year‐old woman with metastatic liver disease derived from right advanced renal pelvis, ureteral cancer, and bladder cancer. She was successfully treated with 0.6 mg/kg daily prednisolone. In patients treated with ICIs, ICI‐induced hepatitis is occasionally observed. Even if patients are older, it appears important to diagnose and treat ICI‐induced hepatitis earlier by multidisciplinary therapies including steroid treatment. This is a first report of pembrolizumab‐induced liver failure in elder patient with age over 80 years. Even if patients are older, it appears important to diagnose and treat ICI‐induced hepatitis earlier by multidisciplinary therapies including steroid treatment. We experienced the occurrence of liver failure after the use of pembrolizumab in an 82‐year‐old woman with metastatic liver disease. Immune checkpoint inhibitor‐induced hepatitis is occasionally observed. It seems important to diagnose and treat older patients with immune checkpoint inhibitor‐induced hepatitis earlier by multidisciplinary therapies. |
| Databáze: | OpenAIRE |
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