Efficacy of further attempts to mobilize CD34+ peripheral stem cells with alternative procedures after primary failure
| Autor: | William Krüger, H. Colberg, Nicolaus Kröger, H.T. Hassan, Kai Gutensohn, Gunter Schuch, R. Kuse, Axel R. Zander, C. Löliger, Helmut Renges, C. Rauhöft, W. Zeller, G Wacker-Backhaus |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.medical_treatment Urology CD34 Antigens CD34 Cell Count Cell Movement Granulocyte Colony-Stimulating Factor Medicine Humans Child Cell yield Chemotherapy Mobilization business.industry Stem Cells Significant difference Peripheral Stem Cells Hematology General Medicine Middle Aged Hematopoietic Stem Cell Mobilization Granulocyte colony-stimulating factor Surgery Stem cell business |
| Zdroj: | Acta haematologica. 102(3) |
| ISSN: | 0001-5792 |
| Popis: | 19 patients who failed the target collection of at least 2.5 × 106 CD34+ cells/kg underwent further mobilization procedures either with granulocyte-colony-stimulating factor (G-CSF) alone after failure to chemotherapy plus G-CSF (group 1), or with chemotherapy plus G-CSF (group 2), or with high-dose G-CSF (24 μg/kg) alone (group 3) after failure to respond to standard dose of G-CSF (10 μg/kg) alone. In all groups, an increase in median CD34+ cell yield could be observed following alternative procedures (1.1- to 1.9 × 106 kg; p = 0.02). The highest increase in CD34+ cell harvest was achieved in group 1 (0.85 to 2.2 × 106 kg), followed by group 2 (1.2 to 1.7) and group 3 (1.0 to 1.4), but without statistically significant difference between the mobilization technologies. All patients with more than 1.0 × 106 CD34+ cells/kg in the first apheresis procedure reached the overall target of 2.5 × 106 CD34+ cells/kg after a second or subsequent mobilization procedure. In contrast, only 3 of 8 patients (37%) with less than 1.0 × 106 CD34+ cells in the first harvest could reach the target of 2.5 × 106 CD34+ cells after further mobilization attempts. |
| Databáze: | OpenAIRE |
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