Gene-gene interaction in the RAS system in the predisposition to myocardial infarction in elder population of St. Petersburg (Russia)
| Autor: | Svetlana P. Gukova, Valentina I. Larionova-Vasina, E.I. Schwartz, Yuri R. Kovalev, Ekaterina V. Fomicheva |
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| Rok vydání: | 2000 |
| Předmět: |
Oncology
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Population Angiotensinogen Myocardial Infarction Biology Peptidyl-Dipeptidase A Biochemistry Russia Renin-Angiotensin System Endocrinology Gene interaction Gene Frequency Polymorphism (computer science) Internal medicine Genotype Genetics medicine Humans Genetic Predisposition to Disease Myocardial infarction Allele education Child Molecular Biology Gene Alleles Aged Sequence Deletion Aged 80 and over education.field_of_study Polymorphism Genetic Homozygote Epistasis Genetic Middle Aged medicine.disease Amino Acid Substitution Epistasis |
| Zdroj: | Molecular genetics and metabolism. 69(1) |
| ISSN: | 1096-7192 |
| Popis: | The aim of this study was to estimate the frequencies of some DNA polymorphisms of two genes of the renin-angiotensin system (RAS), M235T angiotensinogen gene and insertion-deletion polymorphism in angiotensin-converting enzyme gene, in older (>55 years old) myocardial infarction survival and control groups. For this purpose 198 myocardial infarction (MI) patients and 152 randomly selected healthy persons have been analyzed. We have not found any differences in allele and genotype distribution in the above-mentioned genes for either group. However, statistical research showed a significant increase of double homozygotes IITT in the group of MI patients as compared with those in the control group. In this respect we suggested that gene-gene interaction in the RAS system may be considered to be a predisposing factor for MI development. |
| Databáze: | OpenAIRE |
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