Secondary metabolites changes in germinated barley and its relationship to anti-wrinkle activity
| Autor: | Jeoungjin Ryu, Ah-Reum Cho, Mi Kyung Sung, Seunghyun Kang, Ji Hwoon Baek, Sang Cheol Park, Qianwen Wu, Young Pyo Jang, Eun-yi Ko |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Statistical methods
Metabolite Science Germination 01 natural sciences Article Collagen Type I chemistry.chemical_compound medicine Humans Food science Cells Cultured Active ingredient Multidisciplinary Plant Extracts 010405 organic chemistry Chemistry 010401 analytical chemistry food and beverages Hordeum Dermis Fibroblasts In vitro Skin Aging 0104 chemical sciences Proanthocyanidin Metabolome Collagenase Medicine Hordeum vulgare Secondary metabolism Matrix Metalloproteinase 1 Prodelphinidin medicine.drug |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | The purpose of this research was to identify metabolite change during barley (Hordeum vulgare) germination and reveal active principles for the anti-wrinkle activity. Barley was germinated with deionized water (DW) and mineral-rich water (MRW) for the comparison of the effect of mineral contents on the metabolites changes during germination. The effects of germinated barley extracts (GBEs) on collagen production and collagenase inhibition were evaluated in vitro using human dermal fibroblasts (HDFs). A pronounced anti-wrinkle activity was observed in the test group treated with the MRW-GBEs. In order to find out the active components related to the anti-wrinkle activity, an orthogonal projection to latent structure-discriminant analysis (OPLS-DA) was performed, using the data from secondary metabolites profiling conducted by UPLC–PDA–ESI–MS. The anti-wrinkle activity of MRW-GBEs was revealed to be associated with the increase of oligomeric compounds of procyanidin and prodelphinidin, indicating that it can be used as an active ingredient for anti-wrinkle agents. |
| Databáze: | OpenAIRE |
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