Relationship between maternal bone biomarkers and fetal adiposity through normal pregnancy
| Autor: | George Farmakides, George Mastorakos, Ioannis Papassotiriou, Thomas M. Barber, Alexandra Bargiota, Spyridoula Kasioni, Sudhesh Kumar, Dimosthenis Maliopoulos, Nikos F. Vlahos, Chrysanthi Skevaki, N Vrachnis, Georgios Valsamakis |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Endocrinology Diabetes and Metabolism Clinical Biochemistry Biochemistry Body Mass Index chemistry.chemical_compound 0302 clinical medicine Endocrinology Pregnancy Abdomen Medicine Birth Weight Prospective Studies Adiposity biology Pregnancy Trimester Second Osteocalcin Female Pregnancy Trimesters Waist Circumference Adult medicine.medical_specialty RJ Birth weight Abdominal Fat 030209 endocrinology & metabolism Ultrasonography Prenatal 03 medical and health sciences Fetus Internal medicine Humans Adaptor Proteins Signal Transducing Calcifediol business.industry Biochemistry (medical) RANK Ligand Infant Newborn Anthropometry medicine.disease R1 030104 developmental biology chemistry biology.protein Sclerostin RG business Body mass index Biomarkers Blood sampling RC |
| ISSN: | 0021-972X |
| Popis: | Purpose To examine the association of maternal bone markers [sclerostin, soluble receptor activator of nuclear factor-κB ligand (sRANKL), osteocalcin, 25-hydroxyvitamin D3] with fetal intra-abdominal and subcutaneous adipose tissue deposition and birthweight during normal pregnancy. Methods One hundred pregnant women (aged 30.4 ± 5.6 years, mean ± SD) with prepregnancy body mass index = 24.1 ± 4.6 kg/m2 were seen prospectively during each trimester. At each visit they were submitted to anthropometric measurements, a fasting blood sampling, a 75-g oral glucose tolerance test, and a fetal ultrasonogram. At birth, neonates had birth weight measurement. Results In the second trimester, maternal sclerostin concentrations correlated positively with fetal abdominal circumference and birth weight; maternal sRANKL concentrations correlated positively with fetal abdominal subcutaneous fat thickness, sagittal abdominal diameter, and abdominal circumference. Fetuses born to mothers with greater (>254 ng/mL), compared to fetuses born to mothers with lower (≤254ng/mL), sRANKL concentrations had greater abdominal circumference, sagittal diameter, and abdominal subcutaneous fat thickness. Maternal serum sclerostin concentrations were the best positive predictors of birth weight. In the third trimester maternal sclerostin concentrations correlated positively with fetal sagittal abdominal diameter; maternal sRANKL concentrations positively correlated with fetal abdominal circumference and fetal abdominal sagittal diameter. Conclusions Maternal bone markers sclerostin and sRANKL may relate to fetal intra-abdominal adipose tissue deposition through as yet unknown direct or indirect mechanisms, thus contributing to birthweight. |
| Databáze: | OpenAIRE |
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