Modification of the beta-adrenergic sensitivity of rat submandibular gland by constant light
| Autor: | S. L. Bellavia, Raquel Vivian Gallará |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Saliva Light medicine.medical_treatment Photoperiod Submandibular Gland Reversion Internal medicine Receptors Adrenergic beta medicine Animals Rats Wistar General Dentistry Constant light Desensitization (medicine) photoperiodism Dose-Response Relationship Drug Chemistry Isoproterenol β adrenergic Cell Biology General Medicine Organ Size Submandibular gland Stimulation Chemical Rats Endocrinology medicine.anatomical_structure Salivary secretion Otorhinolaryngology Secretory Rate |
| Zdroj: | Archives of oral biology. 40(1) |
| ISSN: | 0003-9969 |
| Popis: | Rats exposed for 2, 5, 10, 20, 35 and 50 days to constant light (CL) showed beta-adrenergic desensitization of the submandibular gland as indicated by dose-response curves to 1.5, 2.0, 3.0, 10.0, 30.0 and 50.0 micrograms/kg isoproterenol. The phenomenon, evident with 1.5, 2.0 and 50.0 micrograms/kg after 2 days at CL, was more intense as time of exposure increased to reach values of about 50% those for controls after 20 days. After 35 and 50 days, desensitization showed some reversion, but the secretory responses were still lower than for controls maintained under a typical photoperiod. In the groups of rats exposed to CL for 20 days, gland wet and dry weights were higher (10%) than those of controls. These changes probably indicate an adaptation of the sympathetic control of salivary secretion induced by environmental illumination. |
| Databáze: | OpenAIRE |
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