Aortic stiffness and kidney disease in an elderly population
| Autor: | Margret B. Andresdottir, Katherine H. Michener, Naya Huang, Vilmundur Gudnason, Andrew S. Levey, Runolfur Palsson, Tamara B. Harris, Gary F. Mitchell, Farzad Noubary |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty 030232 urology & nephrology Iceland Renal function 030204 cardiovascular system & hematology Pulse Wave Analysis Article Renal Circulation Cohort Studies 03 medical and health sciences 0302 clinical medicine Vascular Stiffness Internal medicine medicine.artery medicine Albuminuria Humans Arterial Pressure Prospective Studies Cystatin C Renal Insufficiency Chronic Aorta Aged Aged 80 and over biology business.industry medicine.disease Femoral Artery Blood pressure Carotid Arteries Nephrology Cardiovascular Diseases Creatinine Microvessels biology.protein Cardiology Linear Models Aortic stiffness Female medicine.symptom business Kidney disease Cohort study Glomerular Filtration Rate |
| Zdroj: | American journal of nephrology. 41(4-5) |
| ISSN: | 1421-9670 |
| Popis: | Background/Aims: The causes of chronic kidney disease (CKD) in older people are not well understood. Aortic stiffness increases with age and results in the transmission of increased pulsatility into the kidney microvasculature, potentially contributing to CKD in older populations. Methods: We utilized data from the Age, Gene/Environment, Susceptibility-Reykjavik Study, a community-based prospective cohort study of cardiovascular disease (CVD) in Iceland. The relationship of carotid pulse pressure (CPP) and carotid-femoral pulse wave velocity (CFPWV) with estimated glomerular filtration rate (eGFR) based on creatinine and cystatin C and urine albumin-creatinine ratio (ACR) was assessed using linear regression, adjusting for demographics and CVD risk factors. Results: 940 participants (mean (SD) age 75.8 (4.7) years, mean (SD) CFPWV 12.9 (4.2) m/s, mean (SD) CPP 69 (21) mm Hg, mean (SD) eGFR 68 (16) ml/min/1.73 m2, and median (IQR) ACR 3 (2-6) mg/g) were included in this study. At CPP greater than 85 mm Hg, a higher CPP was associated with a lower eGFR in unadjusted analyses but not after adjustment. CPP was significantly associated with a higher ACR in fully adjusted models (β (95% CI) = 0.14 (0.03, 0.24) ln mg/g per SD). Higher CFPWV was associated with lower eGFR and higher ACR in unadjusted analyses but not after adjustment. Conclusion: Greater aortic stiffness may be associated with modestly higher levels of albuminuria in the elderly. The association between aortic stiffness and lower eGFR may be confounded by age and CVD risk factors. |
| Databáze: | OpenAIRE |
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