Effects of long-term infusions of dopa and carbidopa on renin and steroid secretion in the rat
| Autor: | G C Inglis, C. J. Kenyon |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Dopamine Kidney Rats Sprague-Dawley chemistry.chemical_compound Endocrinology Adrenal Cortex Hormones Corticosterone Internal medicine Renin Renin–angiotensin system medicine Animals Desoxycorticosterone Aldosterone Carbidopa Dihydroxyphenylalanine Rats medicine.anatomical_structure chemistry Zona glomerulosa Adrenal Cortex Catecholamine medicine.drug |
| Zdroj: | Endocrinology. 131:2941-2945 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo.131.6.1446631 |
| Popis: | Plasma, kidney, and adrenal catecholamine concentrations were varied by infusing rats with L-dopa and/or carbidopa for 2 weeks. L-Dopa infusion (300 micrograms/day) increased dopamine concentrations in plasma, adrenal zona glomerulosa, and kidney by 140%, 74%, and 224%, respectively: the dopamine content of the adrenal inner cortex plus medulla was not increased. Infusion of carbidopa alone had no detectable effect upon endogenous dopamine concentrations. Concomitant infusion (300 micrograms/day) of carbidopa with L-dopa blocked the rise in plasma and adrenocortical dopamine caused by L-dopa alone. Plasma aldosterone and plasma and kidney active renin concentrations were unaffected by L-dopa administration but plasma corticosterone and deoxycorticosterone (DOC) were significantly elevated (P0.05); increases in DOC appeared greater than those of corticosterone. These data cast doubt on the theory that dopamine is a physiological tonic inhibitor of aldosterone synthesis in rats. However, in the rat, stimulatory effects of L-dopa on plasma concentrations of precursors of aldosterone might be of physiological significance since DOC is a potent mineralocorticoid. |
| Databáze: | OpenAIRE |
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