Caffeine Ingestion Before an Oral Glucose Tolerance Test Impairs Blood Glucose Management in Men with Type 2 Diabetes
| Autor: | Danielle S. Battram, Premila Sathasivam, Drew H. McLaren, Terry E. Graham, Lindsay E. Robinson, Sonali Savani |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty medicine.medical_treatment Medicine (miscellaneous) Type 2 diabetes chemistry.chemical_compound Insulin resistance Double-Blind Method Caffeine Internal medicine Diabetes mellitus Diabetes Mellitus medicine Hyperinsulinemia Humans Insulin Glucose homeostasis Obesity Glucose tolerance test Nutrition and Dietetics medicine.diagnostic_test C-peptide business.industry Glucose Tolerance Test Middle Aged medicine.disease Glucose Endocrinology Diabetes Mellitus Type 2 chemistry Area Under Curve Insulin Resistance business Proinsulin |
| Zdroj: | The Journal of Nutrition. 134:2528-2533 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/134.10.2528 |
| Popis: | Caffeine ingestion negatively affects insulin sensitivity during an oral glucose tolerance test (OGTT) in lean and obese men, but this has not been studied in individuals with type 2 diabetes. We examined the effects of caffeine ingestion on insulin and glucose homeostasis in obese men with type 2 diabetes. Men (n = 12) with type 2 diabetes (age = 49 +/- 2 y, BMI = 32 +/- 1 kg/m(2)) underwent 2 trials, 1 wk apart, in a randomized, double-blind design. Each trial was conducted after withdrawal from caffeine, alcohol, exercise, and oral hypoglycemic agents for 48 h and an overnight fast. Subjects randomly ingested caffeine (5 mg/kg body weight) or placebo capsules and 1 h later began a 3 h 75 g OGTT. Caffeine increased (P < 0.05) serum insulin, proinsulin, and C-peptide concentrations during the OGTT relative to placebo. Insulin area under the curve was 25% greater (P < 0.05) after caffeine than after placebo ingestion. Despite this, blood glucose concentration was also increased (P < 0.01) in the caffeine trial. After caffeine ingestion, blood glucose remained elevated (P < 0.01) at 3 h postglucose load (8.9 +/- 0.7 mmol/L) compared with baseline (6.7 +/- 0.4 mmol/L). The insulin sensitivity index was lower (14%, P = 0.02) after caffeine than after placebo ingestion. Overall, despite elevated and prolonged proinsulin, C-peptide, and insulin responses after caffeine ingestion, blood glucose was also increased, suggesting an acute caffeine-induced impairment in blood glucose management in men with type 2 diabetes. |
| Databáze: | OpenAIRE |
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