Prevalence of Anal Dysplasia in Patients With Inflammatory Bowel Disease
| Autor: | Carlos E. Pineda, Saif Ghole, Reet Pai, Mark L. Welton, Christina S. Kong, Danielle M. Pickham, Hiwot Araya, Lauren Shih, Shamita B. Shah, Ahmad Kamal |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Papanicolaou stain Inflammatory bowel disease Gastroenterology Young Adult Internal medicine medicine Prevalence Anal cancer Humans Papillomaviridae Aged Aged 80 and over Crohn's disease Hepatology business.industry Anal dysplasia Middle Aged medicine.disease Anus Neoplasms Inflammatory Bowel Diseases Ulcerative colitis digestive system diseases Squamous intraepithelial lesion Cross-Sectional Studies Cohort Female business Precancerous Conditions Papanicolaou Test |
| Zdroj: | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 13(11) |
| ISSN: | 1542-7714 |
| Popis: | Background & Aims Although the prevalence of anal dysplasia is higher in some immunosuppressed populations, the prevalence in patients with inflammatory bowel disease (IBD) is unknown. We examined the prevalence of abnormal anal cytology among IBD patients, and its relation to the human papilloma virus (HPV). Methods Adults with IBD and age-matched healthy controls (HC) were recruited. IBD patients were categorized as nonimmunosuppressed (IBD-N) or immunosuppressed (IBD-I). Anal Papanicolaou tests were performed for HPV testing and classification by a cytopathologist as follows: negative, atypical squamous cells of undetermined significance (ASC-US), low-grade squamous intraepithelial lesion, high-grade squamous intraepithelial lesion, cancer, or unsatisfactory. Results A total of 270 subjects (100 IBD-I, 94 IBD-N, and 76 HC) were recruited. ASC-US were detected in 19 subjects, with a trend toward a higher prevalence among IBD subjects compared with HC (8.8% vs 2.6%; P = .10). The prevalence did not differ with respect to immunosuppression. Crohn's disease (CD) subjects had a higher prevalence of ASC-US compared with others with IBD ( P = .02). Among those with CD, female sex and disease duration longer than 10 years were risk factors. There were no cases of low-grade squamous intraepithelial lesion, high-grade squamous intraepithelial lesion, or anal cancer in the cohort. HPV was present in 5.3% and 1.5% of subjects with and without ASC-US, respectively ( P = .26). Conclusions Although there was a trend toward abnormal anal Papanicolaou tests in IBD subjects compared with HC, there was no difference based on immunosuppression. The presence of HPV did not correlate with abnormal anal cytology. Risk factors associated with this increased trend include female CD subjects and those with a longer duration of CD. ClinicalTrials.gov number: NCT01860963; https://clinicaltrials.gov/ct2/show/NCT01860963. |
| Databáze: | OpenAIRE |
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