Poly-ε-caprolactone scaffold for the reinforcement of stapled small intestinal anastomoses:a randomized experimental study
| Autor: | Mark Bremholm Ellebæk, M Westerholt, Niels Qvist, K D Larsen, G I Madsen, Dang Quang Svend Le |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Swine Anastomotic Leak Anastomosis Statistics Nonparametric 03 medical and health sciences Lactones Random Allocation 0302 clinical medicine Reference Values Tensile Strength Ultimate tensile strength Intestine Small Surgical Stapling medicine Animals Caproates Tissue Scaffolds business.industry Anastomosis Surgical Vascular surgery Small intestine Colorectal surgery Surgery Disease Models Animal medicine.anatomical_structure Cardiothoracic surgery 030220 oncology & carcinogenesis Swine Miniature 030211 gastroenterology & hepatology Female business Wound healing Abdominal surgery |
| Zdroj: | Kasper, L, Westerholt, M, Larsen, G, Le, D Q S, Qvist, N & Ellebæk, M 2019, ' Poly-ε-caprolactone scaffold for the reinforcement of stapled small intestinal anastomoses : a randomized experimental study ', Langenbecks Archives of Surgery, vol. 404, no. 8, pp. 1009-1016 . https://doi.org/10.1007/s00423-019-01843-5 Larsen, K D, Westerholt, M, Madsen, G I, Le, D Q S, Qvist, N & Ellebæk, M B 2019, ' Poly-ε-caprolactone scaffold for the reinforcement of stapled small intestinal anastomoses : a randomized experimental study ', Langenbeck's Archives of Surgery, vol. 404, no. 8, pp. 1009-1016 . https://doi.org/10.1007/s00423-019-01843-5 |
| Popis: | BackgroundAnastomotic leakage is a severe complication in gastrointestinal surgery. Different methods have been evaluated for anastomotic reinforcement to prevent anastomotic leakage. The aim of this study was to investigate the effect of a poly-ε-caprolactone (PCL) scaffold incorporated in the staple-line, on the anastomotic strength and histological wound healing, of small intestinal anastomoses in piglets.MethodThis randomized experimental trial included 17 piglets. In each piglet, three end-to-end anastomoses were performed in the small intestine with a circular stapler, i.e. one control and two interventional anastomoses. On postoperative day 5, the anastomoses were resected and subjected to tension stretch test and histological examination.ResultsNo anastomotic leakage occurred. In the interventional anastomoses, the mean value for maximal tensile strength was 15.7 N, which was significantly higher than control anastomoses 12.7 N (p = 0.01). No statistically significant differences were found between the two groups in the histopathological parameters.ConclusionTo conclude, this study has shown that the incorporation of a PCL scaffold in the staple-line was feasible and significantly increased the maximal tensile strength of small intestine anastomoses in piglets on postoperative day 5. The difference in histological parameters was not significantly distinct. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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