Mechanism of Development of Plutonium-induced Pulmonary Sclerosis
| Autor: | Mushkacheva Gs, Poplyko Mg, Tseveleva Ia, Lemberg Vk, Aristov Vp, Koshurnikova Na |
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| Rok vydání: | 1972 |
| Předmět: |
Lung Diseases
Pathology medicine.medical_specialty Time Factors Epidemiology Health Toxicology and Mutagenesis Basement Membrane Phagocytosis Parenchyma medicine Humans Radiology Nuclear Medicine and imaging Radiation Injuries Lung Radiation injury Aerosols Sclerosis Inhalation Chemistry Mechanism (biology) Regeneration (biology) Fibroblasts Plutonium Capillaries Pulmonary Alveoli Radiation Effects Microscopy Electron PULMONARY SCLEROSIS Cell Division |
| Zdroj: | Health Physics. 22:753-754 |
| ISSN: | 0017-9078 |
| Popis: | The mechanism of development of plutonium-induced pulmonary sclerosis following the inhalation of soluble plutonium compounds was studied by light and electron microscopy and with biochemical methods. Plutonium-induced pulmonary sclerosis is a consequence of radiation injury. The effects seen are due to excessive reparative functioning of connectivetissue when disturbance of physiological regeneration takes place, and due to intensified destruction of parenchyma as a result of radiation injury. Endothelial elements of capillaries show the greatest susceptibility to radiation damage. Interalveolar sclerosis develops as a consequence of intensified proliferation of fibroblasts. Collagen fibers are formed in the basal layer of the alveolar-capillary barrier and in positions previously occupied by capillaries. Infection and the consequent aggravation of pneumonic processes is a significant factor in development of sclerosis. |
| Databáze: | OpenAIRE |
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