Electrospun nanofibers as support for the healing of intestinal anastomoses
| Autor: | M. Vjaclovsky, Evžen Amler, F. Rustichelli, Jiří Hoch, M. Kralovic, A Kestlerová |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Physiology Nanofibers Rectum Anastomotic Leak Biocompatible Materials 030204 cardiovascular system & hematology Anastomosis Sepsis 03 medical and health sciences Peritoneal cavity 0302 clinical medicine Electrospun nanofibers medicine Animals Humans Regeneration business.industry Regeneration (biology) Anastomosis Surgical General Medicine medicine.disease Surgery Intestines medicine.anatomical_structure Nanofiber Complication business 030217 neurology & neurosurgery |
| Zdroj: | Physiological research. 68(Suppl 4) |
| ISSN: | 1802-9973 |
| Popis: | The breakdown of intestinal anastomosis is a serious postsurgical complication. The worst complication is anastomotic leakage, resulting in contaminated peritoneal cavity, sepsis, multi-organ failure and even death. In problematic locations like the rectum, the leakage rate has not yet fallen below 10 %. Such a life-threatening condition is the result of impaired healing in the anastomotic wound. It is still vital to find innovative strategies and techniques in order to support regeneration of the anastomotic wound. This paper reviews the surgical techniques and biomaterials used, tested or published. Electrospun nanofibers are introduced as a novel and potential material in gastrointestinal surgery. Nanofibers possess several, unique, physical and chemical properties, that may effectively stimulate cell proliferation and collagen production; a key requirement for the healed intestinal wound. |
| Databáze: | OpenAIRE |
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