An ultra-stable redox-controlled self-assembling polypeptide nanotube for targeted imaging and therapy in cancer
| Autor: | Gitanjali Asampille, Abhijith Shettar, Steven A. Rosenzweig, Monalisa Swain, Hanudatta S. Atreya, Paturu Kondaiah, Brijesh Kumar Verma |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Nanotube lcsh:Medical technology lcsh:Biotechnology Integrin Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Bioengineering 02 engineering and technology Applied Microbiology and Biotechnology 03 medical and health sciences Neoplasms lcsh:TP248.13-248.65 medicine Humans Molecular Targeted Therapy RGD motif Cancer Molecular switch Molecular Reproduction Development & Genetics Nanotubes biology Integrin targeting Chemistry Research Optical Imaging NMR Research Centre (Formerly Sophisticated Instruments Facility) Solid State & Structural Chemistry Unit Self-assembly 021001 nanoscience & nanotechnology medicine.disease Protein nanotube 030104 developmental biology lcsh:R855-855.5 Covalent bond Cancer cell Biophysics biology.protein Molecular Medicine Protein Multimerization Peptides 0210 nano-technology Oxidation-Reduction Intermolecular disulfide bonds |
| Zdroj: | Journal of Nanobiotechnology, Vol 16, Iss 1, Pp 1-14 (2018) Journal of Nanobiotechnology |
| Popis: | We introduce a self-assembling polypeptide-based nanotube system having the ability to specifically target cancer cells. The nanotubes target the cancer cell surface through integrin engagement with the help of multiple RGD units present along their surface. While the nanotubes are non-toxic towards cells in general, they can be loaded with suitable drugs to be released in a sustained manner in cancer cells. In addition, the nanotubes can be utilized for cellular imaging using any covalently tagged fluorescent dye. They are stable over a wide range of temperature due to intermolecular disulphide bonds formed during the self-assembly process. At the same time, presence of disulphide bonds provides a redox molecular switch for their degradation. Taken together this system provides a unique avenue for multimodal formulation in cancer therapy. Electronic supplementary material The online version of this article (10.1186/s12951-018-0427-1) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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