Nanomaterial-based Optical and Electrochemical Biosensors for Amyloid beta and Tau: Potential for early diagnosis of Alzheimer's Disease
| Autor: | Won Woo Cho, Sungbo Cho, Sang-Myung Lee, Le Minh Tu Phan, Jae Young Kim, Hien Thi Ngoc Le, Somasekhar R. Chinnadayyala, Thi Xoan Hoang, Young Hyo Kim, Thuy Anh Thu Vo, Hoang Lan Pham, Seong Hye Choi |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Amyloid beta Nanotechnology tau Proteins Disease Biosensing Techniques Diagnostic tools Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Genetics medicine Dementia Electrochemical biosensor Humans Molecular Biology Amyloid beta-Peptides biology business.industry Optical biosensor medicine.disease Nanostructures 030104 developmental biology Early Diagnosis 030220 oncology & carcinogenesis biology.protein Molecular Medicine business |
| Zdroj: | Expert review of molecular diagnostics. 21(2) |
| ISSN: | 1744-8352 |
| Popis: | Alzheimer's disease (AD), a heterogeneous pathological process representing the most common causes of dementia worldwide, has required early and accurate diagnostic tools. Neuropathological hallmarks of AD involve the aberrant accumulation of Amyloid beta (Aβ) into Amyloid plaques and hyperphosphorylated Tau into neurofibrillary tangles, occurring long before the onset of brain dysfunction.The study has identified the potential application of advanced biosensors as standardized clinical diagnostic tools for AD, evolving the way for new and efficient AD control with minimum economic and social burden. After clinical trial, nanobiosensors for measuring Aβ and Tau simultaneously possess innovative diagnosis of AD to provide significant contributions to primary Alzheimer's care intervention. |
| Databáze: | OpenAIRE |
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