Outcome of T1N0M0 Squamous Cell Carcinoma of the Larynx Treated with Short-course Radiotherapy to a Total Dose of 50 Gy in 16 Fractions: the Birmingham Experience
| Autor: | Andrea Marshall, N.L.C. Cheah, Andrew Hartley, J. Glaholm, S.C. Lupton |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Larynx medicine.medical_specialty Glottis medicine.medical_treatment Disease-Free Survival medicine Humans Radiology Nuclear Medicine and imaging Basal cell Neoplasms Squamous Cell Laryngeal Neoplasms Aged Neoplasm Staging Aged 80 and over Lung business.industry Dose fractionation Cancer Middle Aged medicine.disease Surgery Radiation therapy Treatment Outcome medicine.anatomical_structure Oncology Total dose Female Dose Fractionation Radiation business Follow-Up Studies |
| Zdroj: | Clinical Oncology. 21:494-501 |
| ISSN: | 0936-6555 |
| Popis: | Aims To review the results of hypofractionated radiotherapy in T1N0M0 squamous cell carcinoma of the larynx. Materials and methods A series of 100 patients treated with radiotherapy between 1993 and 2001 was reviewed. The median age was 67 years. The median follow-up was 7 years (range 3–14 years). Radiotherapy was delivered to a total dose of 50 Gy in 16 fractions treating daily, 5 days a week over 21 days. Results Locoregional control rates with radiotherapy alone were 92% at 2 years and 88% at 5 years. After salvage surgery, the ultimate locoregional control rate was 96%. The relapse-free survival rates at 2 and 5 years were 85 and 70%, respectively. The cause-specific survival rates at 2 and 5 years were 99 and 97%, respectively. Overall survival rates at 2 and 5 years were 91 and 76%, respectively. Second primary cancers occurred in 21% of patients, primarily in the lung. Conclusions Radiotherapy to a total dose of 50 Gy in 16 fractions for T1N0M0 squamous cell carcinoma of the larynx offers high locoregional control rates with voice preservation. These results from a hypofractionated radiotherapy schedule are comparable with other longer fractionation schedules and offer potential for optimising resource usage. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect