R-PEP-27, a potent renin inhibitor, decreases plasma angiotensin II and blood pressure in normal volunteers
| Autor: | Randall M. Zusman, David A. Schoenfeld, Kwan Y. Hui, Jürg Nussberger, Edgar Haber, Donna M. Christensen, Joy Higgins, William D. Carlson |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Hemodynamics Blood Pressure Urine Renin inhibitor chemistry.chemical_compound Reference Values Internal medicine Renin–angiotensin system Blood plasma Renin Internal Medicine medicine Homeostasis Humans Aldosterone Adult Aldosterone/blood Angiotensin II/*blood Blood Pressure/*drug effects Female Homeostasis Humans Male Middle Aged Oligopeptides/adverse effects/*pharmacology Osmolar Concentration Reference Values Renin/*antagonists & inhibitors Urine/chemistry business.industry Angiotensin II Osmolar Concentration Middle Aged Endocrinology Blood pressure chemistry Female business Oligopeptides Low sodium |
| Zdroj: | American Journal of Hypertension, vol. 7, no. 4 Pt 1, pp. 295-301 |
| ISSN: | 0895-7061 |
| Popis: | The hemodynamic and humoral effects of the specific human renin inhibitor R-PEP-27 were studied in six normal human subjects on low and high sodium intake diets. An intravenous infusion of R-PEP-27 (0.5 to 16 μg/min/kg body wt) reduced blood pressure in a dose-dependent fashion; the mean arterial blood pressure at the end of the infusion fell from 128 ± 4/83 ± 4 to 119 ± 3/71 ± 3 mm Hg (mean ± SEM) (P < .01) during the low sodium intake diet. R-PEP-27 had no effect on blood pressure during the high sodium intake diet. R-PEP-27 significantly reduced plasma angiotensin II and aldosterone concentrations. The temporal response to R-PEP-27 suggests that it is a shortlived although highly potent competitive inhibitor of renin; this peptide is a valuable and specific physiologic probe of the renin-angiotensin system. Am J Hypertens 1994;7:295-301 |
| Databáze: | OpenAIRE |
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