Localized Prostate Cancer: Effect of Hormone Deprivation Therapy Measured by Using Combined Three-dimensional1H MR Spectroscopy and MR Imaging: Clinicopathologic Case-controlled Study
| Autor: | Daniel B. Vigneron, Hedvig Hricak, Anita Srivastava, Imok Cha, John Kurhanewicz, Ryan G. Males, Mark G. Swanson, Juergen Scheidler, Ullrich G. Mueller-Lisse, André Bessette, Peter R. Carroll |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Magnetic Resonance Spectroscopy Antineoplastic Agents Hormonal medicine.medical_treatment Prostate cancer Prostate medicine Humans Radiology Nuclear Medicine and imaging Observer Variation medicine.diagnostic_test business.industry Prostatectomy Case-control study Prostatic Neoplasms Reproducibility of Results Cancer Magnetic resonance imaging Middle Aged Deuterium medicine.disease Magnetic Resonance Imaging Mr imaging medicine.anatomical_structure Case-Control Studies Goserelin Histopathology Leuprolide Nuclear medicine business |
| Zdroj: | Radiology. 221:380-390 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiol.2211001582 |
| Popis: | To determine the accuracy of combined magnetic resonance (MR) imaging and three-dimensional (3D) proton MR spectroscopic imaging in localizing prostate cancer to a sextant of the gland in patients receiving hormone deprivation therapy.Combined MR imaging/3D MR spectroscopic imaging examinations were performed in 16 hormone-treated patients and 48 nontreated matched control patients before radical prostatectomy and step-section histopathologic analysis. At MR imaging, cancer presence within the peripheral zone was assessed on a per sextant basis by two readers. At 3D MR spectroscopic imaging, cancer was identified by using (choline plus creatine)-to-citrate ratios at cutoff values of 2 and 3 SDs above mean normal peripheral zone values. Data were compared by using receiver operating characteristic analysis.There was no significant difference in the ability of combined MR imaging/3D MR spectroscopic imaging to localize prostate cancer in treated versus control patients. For MR imaging alone, the sensitivity and specificity were 91% and 48% (reader 1) and 75% and 60% (reader 2) in treated patients versus 79% and 60% (reader 1) and 84% and 43% (reader 2) in control patients. For 3D MR spectroscopic imaging alone (3 SDs cutoff), higher specificity (treated, 80%; controls, 73%) but lower sensitivity (treated, 56%; controls, 53%) was attained. In treated patients, high sensitivity or specificity (up to 92%) was achieved when either or both modalities indicated cancer.When performed within 4 months after initiating hormone deprivation therapy, combined MR imaging/3D MR spectroscopic imaging had the same accuracy in localizing prostate cancer as in nontreated patients. |
| Databáze: | OpenAIRE |
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