Clinical and Molecular Factors Associated With Histologic Response to Topical Steroid Treatment in Patients With Eosinophilic Esophagitis
| Autor: | John T. Woosley, Swathi Eluri, Cara Randall, Spencer Rusin, Evan S. Dellon, Nicholas J. Shaheen, Irina Perjar, Renee Betancourt, Sara R. Selitsky, Johnathan Hollyfield |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Budesonide medicine.medical_specialty medicine.drug_class Administration Topical Biopsy medicine.medical_treatment Proton-pump inhibitor Gastroenterology Article 03 medical and health sciences Esophagus 0302 clinical medicine Internal medicine medicine Humans Prospective Studies Eosinophilic esophagitis Glucocorticoids Fluticasone Hepatology business.industry Area under the curve Eosinophilic Esophagitis Odds ratio medicine.disease Treatment Outcome 030220 oncology & carcinogenesis Biomarker (medicine) Female 030211 gastroenterology & hepatology Esophagoscopy business Biomarkers Follow-Up Studies medicine.drug Topical steroid |
| Zdroj: | Clin Gastroenterol Hepatol |
| ISSN: | 1542-3565 |
| DOI: | 10.1016/j.cgh.2018.09.005 |
| Popis: | BACKGROUND AND AIMS: Few factors have been identified that can be used to predict response of patients with eosinophilic esophagitis (EoE) to topical steroid treatment. We aimed to determine whether baseline clinical, endoscopic, histologic, and molecular features of EoE can be used to predict histologic response. METHODS: We collected data from 97 patients with EoE, from 2009 through 2015, treated with a topical steroid for 8 weeks; 59 patients had a histologic response to treatment. Baseline clinicopathologic features and gene expression patterns were compared between patients with a histologic response to treatment ( |
| Databáze: | OpenAIRE |
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