Nonelectrolyte fluxes across gastric mucosa in relation to gastric stimulation

Autor: Trifone Schettino, C. Lora Lamina-Donin, Claudio Lippe, D. Cremaschi, Franco Cotelli
Přispěvatelé: Schettino, Trifone, Cremaschi, D., Lippe, C., Lamina Donin, C., Cotelli, F.
Rok vydání: 1980
Předmět:
Zdroj: Pfl�gers Archiv European Journal of Physiology. 387:269-279
ISSN: 1432-2013
0031-6768
DOI: 10.1007/bf00580980
Popis: The effects of histamine and thiocyanate, added to the serosal bathing solution, on unidirectional fluxes of some nonelectrolytes (thiourea, methylated thiourea derivates, mannitol), and on H+, pepsinogen and mucous secretion were investigated in frog (Rana esculenta) fundic gastric mucosa. Histamine (10(-4) M) increases significantly the outfluxes (serosa to mucosa fluxes) of only thiourea and its derivates (but not mannitol) and the stimulation is the greater the more lipidsoluble the nonelectrolyte is. Influxes (mucosa to serosa fluxes) of the same molecules are not affected. In parallel histamine stimulates H+-secretion but does not modify pepsinogen and mucous secretion. SCN- (10(-2) M) inhibits the histamine effect on thiourea outfluxes and on H+-secretion, while pepsinogen and mucous secretion are not affected. Colchicine (10(-4) M) pretreatment inhibits the histamine effect on outfluxes and H+-secretion. It is concluded that: (1) histamine induces a secretion of nonelectrolytes towards the lumen; (2) such secretion is correlated with the hormone-induced secretion of HCl and fluid; (3) this process is mediated by an exocytotic mechanism.
Databáze: OpenAIRE
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